{"paper_id":"2a32712d-30e3-4f53-9f0f-3939f9226ca8","body_text":"Advanced Hub Main Navigation Menu\nInterventional Hydrogel Microsphere Controlled-Releasing Curcumin for Photothermal Therapy against Endometriosis\nXuemin Liu\nFirst Affiliated Hospital of Shenzhen University, Reproductive Medicine Centre, Shenzhen Second People's Hospital, Shenzhen, 518035 P. R. China\nSearch for more papers by this authorShengtao Yan\nDepartment of Emergency, China–Japan Friendship Hospital, Beijing, 100029 P. R. China\nSearch for more papers by this authorHongliang Wu\nNational Engineering Research Centre for Tissue Restoration and Reconstruction, South China University of Technology, School of Materials Science and Engineering, South China University of Technology, Guangzhou, 510640 P. R. China\nSearch for more papers by this authorMing Chen\nFirst Affiliated Hospital of Shenzhen University, Reproductive Medicine Centre, Shenzhen Second People's Hospital, Shenzhen, 518035 P. R. China\nSearch for more papers by this authorHao Dai\nNational Engineering Research Centre for Tissue Restoration and Reconstruction, South China University of Technology, School of Materials Science and Engineering, South China University of Technology, Guangzhou, 510640 P. R. China\nSearch for more papers by this authorZhenxing Wang\nNational Engineering Research Centre for Tissue Restoration and Reconstruction, South China University of Technology, School of Materials Science and Engineering, South China University of Technology, Guangzhou, 510640 P. R. China\nSearch for more papers by this authorMuyuan Chai\nNational Engineering Research Centre for Tissue Restoration and Reconstruction, South China University of Technology, School of Materials Science and Engineering, South China University of Technology, Guangzhou, 510640 P. R. China\nSearch for more papers by this authorQingyu Hu\nFirst Affiliated Hospital of Shenzhen University, Reproductive Medicine Centre, Shenzhen Second People's Hospital, Shenzhen, 518035 P. R. China\nSearch for more papers by this authorDongdong Li\nFirst Affiliated Hospital of Shenzhen University, Reproductive Medicine Centre, Shenzhen Second People's Hospital, Shenzhen, 518035 P. R. China\nSearch for more papers by this authorLei Chen\nFirst Affiliated Hospital of Shenzhen University, Reproductive Medicine Centre, Shenzhen Second People's Hospital, Shenzhen, 518035 P. R. China\nSearch for more papers by this authorRuiying Diao\nFirst Affiliated Hospital of Shenzhen University, Reproductive Medicine Centre, Shenzhen Second People's Hospital, Shenzhen, 518035 P. R. China\nSearch for more papers by this authorCorresponding Author\nShi Chen\nFirst Affiliated Hospital of Shenzhen University, Reproductive Medicine Centre, Shenzhen Second People's Hospital, Shenzhen, 518035 P. R. China\nShenzhen Key Laboratory of Microbiology in Genomic Modification and Editing and Application, Shenzhen Institute of Translational Medicine, First Affiliated Hospital of Shenzhen University, Shenzhen Second People's Hospital, Shenzhen, 518035 P. R. China\nE-mail: [email protected]; [email protected]; [email protected]\nSearch for more papers by this authorCorresponding Author\nLiping Wang\nFirst Affiliated Hospital of Shenzhen University, Reproductive Medicine Centre, Shenzhen Second People's Hospital, Shenzhen, 518035 P. R. China\nE-mail: [email protected]; [email protected]; [email protected]\nSearch for more papers by this authorCorresponding Author\nXuetao Shi\nNational Engineering Research Centre for Tissue Restoration and Reconstruction, South China University of Technology, School of Materials Science and Engineering, South China University of Technology, Guangzhou, 510640 P. R. China\nKey Laboratory of Biomedical Engineering of Guangdong Province, South China University of Technology, Key Laboratory of Biomedical Materials and Engineering of the Ministry of Education, South China University of Technology, Guangzhou, 510006 P. R. China\nE-mail: [email protected]; [email protected]; [email protected]\nSearch for more papers by this authorXuemin Liu\nFirst Affiliated Hospital of Shenzhen University, Reproductive Medicine Centre, Shenzhen Second People's Hospital, Shenzhen, 518035 P. R. China\nSearch for more papers by this authorShengtao Yan\nDepartment of Emergency, China–Japan Friendship Hospital, Beijing, 100029 P. R. China\nSearch for more papers by this authorHongliang Wu\nNational Engineering Research Centre for Tissue Restoration and Reconstruction, South China University of Technology, School of Materials Science and Engineering, South China University of Technology, Guangzhou, 510640 P. R. China\nSearch for more papers by this authorMing Chen\nFirst Affiliated Hospital of Shenzhen University, Reproductive Medicine Centre, Shenzhen Second People's Hospital, Shenzhen, 518035 P. R. China\nSearch for more papers by this authorHao Dai\nNational Engineering Research Centre for Tissue Restoration and Reconstruction, South China University of Technology, School of Materials Science and Engineering, South China University of Technology, Guangzhou, 510640 P. R. China\nSearch for more papers by this authorZhenxing Wang\nNational Engineering Research Centre for Tissue Restoration and Reconstruction, South China University of Technology, School of Materials Science and Engineering, South China University of Technology, Guangzhou, 510640 P. R. China\nSearch for more papers by this authorMuyuan Chai\nNational Engineering Research Centre for Tissue Restoration and Reconstruction, South China University of Technology, School of Materials Science and Engineering, South China University of Technology, Guangzhou, 510640 P. R. China\nSearch for more papers by this authorQingyu Hu\nFirst Affiliated Hospital of Shenzhen University, Reproductive Medicine Centre, Shenzhen Second People's Hospital, Shenzhen, 518035 P. R. China\nSearch for more papers by this authorDongdong Li\nFirst Affiliated Hospital of Shenzhen University, Reproductive Medicine Centre, Shenzhen Second People's Hospital, Shenzhen, 518035 P. R. China\nSearch for more papers by this authorLei Chen\nFirst Affiliated Hospital of Shenzhen University, Reproductive Medicine Centre, Shenzhen Second People's Hospital, Shenzhen, 518035 P. R. China\nSearch for more papers by this authorRuiying Diao\nFirst Affiliated Hospital of Shenzhen University, Reproductive Medicine Centre, Shenzhen Second People's Hospital, Shenzhen, 518035 P. R. China\nSearch for more papers by this authorCorresponding Author\nShi Chen\nFirst Affiliated Hospital of Shenzhen University, Reproductive Medicine Centre, Shenzhen Second People's Hospital, Shenzhen, 518035 P. R. China\nShenzhen Key Laboratory of Microbiology in Genomic Modification and Editing and Application, Shenzhen Institute of Translational Medicine, First Affiliated Hospital of Shenzhen University, Shenzhen Second People's Hospital, Shenzhen, 518035 P. R. China\nE-mail: [email protected]; [email protected]; [email protected]\nSearch for more papers by this authorCorresponding Author\nLiping Wang\nFirst Affiliated Hospital of Shenzhen University, Reproductive Medicine Centre, Shenzhen Second People's Hospital, Shenzhen, 518035 P. R. China\nE-mail: [email protected]; [email protected]; [email protected]\nSearch for more papers by this authorCorresponding Author\nXuetao Shi\nNational Engineering Research Centre for Tissue Restoration and Reconstruction, South China University of Technology, School of Materials Science and Engineering, South China University of Technology, Guangzhou, 510640 P. R. China\nKey Laboratory of Biomedical Engineering of Guangdong Province, South China University of Technology, Key Laboratory of Biomedical Materials and Engineering of the Ministry of Education, South China University of Technology, Guangzhou, 510006 P. R. China\nE-mail: [email protected]; [email protected]; [email protected]\nSearch for more papers by this authorAbstract\nEndometriosis is a prevalent gynecological disorder characterized by the presence of endometrial-like tissue outside the uterus, causing chronic pelvic pain, painful periods, and infertility. Despite the common use of hormone therapy and surgical lesion excision in its treatment, there remain significant postoperative risks and potential side effects, with a high recurrence rate. An efficient nonsurgical treatment for this condition is therefore urgently needed. In this study, an interventional hydrogel microsphere with near-infrared (NIR)-controlled curcumin release is developed for the non-invasive thermal therapy of endometriosis. The hydrogel microspheres demonstrate good biocompatibility and photothermal activities, causing the death of endometrial stromal cells under NIR and controlled curcumin (Cur) release. When injected into endometriotic lesions and stimulated by NIR light, the interventional hydrogel microspheres (Cur-FeHMPs) can raise the temperature of the endometriotic lesions to 43.65 °C, inducing endometriotic lesion elimination. Furthermore, the controlled curcumin release from the interventional hydrogel inhibits the proinflammatory environment in endometriosis. The Cur-FeHMPs in combination with NIR present a novel strategy for endometriosis treatment.\nConflict of Interest\nThe authors declare no conflict of interest.\nData Availability Statement\nThe data that support the findings of this study are available in the supplementary material of this article.\nSupporting Information\n| Filename | Description |\n|---|---|\n| adfm202315907-sup-0001-SuppMat.pdf1.6 MB | Supporting Information |\nPlease note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.\nReferences\n- 1P. T. K. Saunders, A. W. Horne, Cell 2021, 184, 2807.\n- 2R. O. Burney, L. C. Giudice, Fertil Steril 2012, 98, 511.\n- 3P. Vercellini, P. Viganò, E. Somigliana, L. Fedele, Nat Rev Endocrinol 2014, 10, 261.\n- 4J. Vallvé-Juanico, S. Houshdaran, L. C. Giudice, Hum Reprod Update 2019, 25, 565.\n- 5D. de Ziegler, B. Borghese, C. Chapron, Lancet 2010, 376, 730.\n- 6A. S. Moses, A. A. Demessie, O. Taratula, T. Korzun, O. D. Slayden, O. Taratula, Small 2021, 17, 2004975.\n- 7R.-L. Ge, P.-N. Yan, Y. Liu, Z.-S. Li, S.-Q. Shen, Y. Yu, Adv. Funct. Mater. 2023, 33, 2301138.\n- 8L. Rethi, C. Mutalik, L. Rethi, W.-H. Chiang, H.-L. Lee, W.-Y. Pan, T.-S. Yang, J.-F. Chiou, Y.-J. Chen, E.-Y. Chuang, L.-S. Lu, Cancers 2022, 14, 5043.\n- 9F. Pelaez, N. Manuchehrabadi, P. Roy, H. Natesan, Y. Wang, E. Racila, H. Fong, K. Zeng, A. M. Silbaugh, J. C. Bischof, S. M. Azarin, Biomaterials 2018, 166, 27.\n- 10J. Chen, C. Ning, Z. Zhou, P. Yu, Y. Zhu, G. Tan, C. Mao, Prog. Mater. Sci. 2019, 99, 1.\n- 11B. Wang, X. He, Z. Zhang, Y. Zhao, W. Feng, Acc. Chem. Res. 2013, 46, 761.\n- 12Z. Wang, G. An, Y. Zhu, X. Liu, Y. Chen, H. Wu, Y. Wang, X. Shi, C. Mao, Mater. Horiz. 2019, 6, 733.\n- 13S. Wang, H. Lu, X. Kang, Z. Wang, S. Yan, X. Zhang, X. Shi, Adv. Funct. Mater. 2023, 2310903, https://doi.org/10.1002/adfm.202310903\n- 14Z. Zhao, Z. Wang, G. Li, Z. Cai, J. Wu, L. Wang, L. Deng, Adv. Funct. Mater. 2021, 2103339, 1.\n- 15J. Bian, F. Cai, H. Chen, Z. Tang, K. Xi, J. Tang, L. Wu, Y. Xu, L. Deng, Y. Gu, W. Cui, L. Chen, Nano Lett. 2021, 21, 2690.\n- 16T. Chen, T. Yao, H. Peng, A. K. Whittaker, Y. Li, S. Zhu, Z. Wang, Adv. Funct. Mater. 2021, 31, 2106079.\n- 17L. Zhang, Y. Zhang, Y. Xue, Y. Wu, Q. Wang, L. Xue, Z. Su, C. Zhang, Adv. Mater. 2019, 31, 1805936.\n- 18Z. Gao, Y. Feng, J. Xu, J. Liang, Front Immunol 2022, 13, 977394.\n- 19A. Siviero, E. Gallo, V. Maggini, L. Gori, A. Mugelli, F. Firenzuoli, A. Vannacci, J Herb Med 2015, 5, 57.\n- 20X. Liu, Y. Chen, A. S. Mao, C. Xuan, Z. Wang, H. Gao, G. An, Y. Zhu, X. Shi, C. Mao, Biomaterials 2020, 232, 119644.\n- 21D. Kumar, M. Kumar, C. Saravanan, S. K. Singh, Expert Opin. Ther. Targets 2012, 16, 959.\n- 22J. Bourquin, A. Milosevic, D. Hauser, R. Lehner, F. Blank, A. Petri-Fink, B. Rothen-Rutishauser, Adv. Mater. 2018, 30, 1704307.\n- 23M. Berbic, L. Schulke, R. Markham, N. Tokushige, P. Russell, I. S. Fraser, Hum Reprod 2009, 24, 325.\n- 24A. Takebayashi, F. Kimura, Y. Kishi, M. Ishida, A. Takahashi, A. Yamanaka, D. Wu, L. Zheng, K. Takahashi, H. Suginami, T. Murakami, Am. J. Reprod. Immunol. 2015, 73, 221.\n- 25G. Yerlikaya, S. Balendran, K. Pröstling, T. Reischer, P. Birner, R. Wenzl, L. Kuessel, B. Streubel, H. Husslein, Eur J Obstet Gyn R B 2016, 204, 88.\n- 26M. Dowsett, T. O. Nielsen, R. A'Hern, J. Bartlett, R. C. Coombes, J. Cuzick, M. Ellis, N. L. Henry, J. C. Hugh, T. Lively, L. McShane, S. Paik, F. Penault-Llorca, L. Prudkin, M. Regan, J. Salter, C. Sotiriou, I. E. Smith, G. Viale, J. A. Zujewski, D. F. Hayes, JNCI, J. Natl. Cancer Inst. 2011, 103, 1656.\n- 27J. S. Park, J. H. Lee, M. Kim, H. J. Chang, K. J. Hwang, K. H. Chang, Fertil Steril 2009, 92, 1246.\n- 28K. K. W. Kuan, D. A. Gibson, L. H. R. Whitaker, A. W. Horne, Front. Reprod. Health 2021, 3, 756704.\n- 29J. Ge, Q. Jia, W. Liu, M. Lan, B. Zhou, L. Guo, H. Zhou, H. Zhang, Y. Wang, Y. Gu, X. Meng, P. Wang, Adv. Healthcare Mater. 2016, 5, 665.\n- 30B. Liu, X. Gu, Q. Sun, S. Jiang, J. Sun, K. Liu, F. Wang, Y. Wei, Adv. Funct. Mater. 2021, 31, 2010779.\n- 31B. Li, T. Gong, N. Xu, F. Cui, B. Yuan, Q. Yuan, H. Sun, L. Wang, J. Liu, Small 2020, 16, 2003969.\nCiting Literature\nArticle Metrics\nTotal unique accesses to an article’s full text in HTML or PDF/ePDF format.More metric information\nScite metrics\nExplore this article's citation statements on scite.ai\nShare QR Code\nGenerating QR code\nQR code copied to clipboard!\nSomething went wrong while generating your QR code. Please try again in a moment. If the issue persists, refresh the page or contact support.\nExport citation\nUnable to load citation data. 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