Advanced healthcare materials

Endometriosis (EuE) is a chronic, incurable disease. Due to limited efficacy, high recurrence rates, and serious side effects of current treatments, development of new, targeted, nonhormonal therapies is urgently needed. We previously repor…

The ascent of novel alternative methods in drug development spotlights the dual needs for improved biological fidelity to in vivo, along with reproducibility, especially in regulatory applications. The need for pre-clinical models of patien…

Preterm birth (PTB), defined as delivery between 28 and 37 weeks of gestation, is a leading cause of global neonatal mortality. Its pathogenesis is primarily driven by oxidative stress and inflammation, synergistically inducing calcium ion …

In this study, a cell-mediated degradable alginate hydrogel system for organoid culture and amenable to biofabrication technologies is presented. Norbornene-functionalized alginate is crosslinked with a di-thiolated peptide sequence cleavab…

Endometriosis (EM) is a non-cancerous disease that exhibits certain tumor-like properties. While hormonal therapies and surgical excision are standard treatments with proven efficacy in alleviating EM symptoms, they are often accompanied by…

Infertility affects ≈17.5% of the adult population worldwide, posing significant clinical, emotional, and socioeconomic challenges. Recent advances at the intersection of reproductive medicine and bioengineering offer promising avenues to e…

Rapid and accurate assessment of conditions characterized by altered blood flow, cardiac blood pooling, or internal bleeding is crucial for diagnosing and treating various clinical conditions. While widely used imaging modalities such as ma…

Myocardial infarction (MI) results in cardiomyocyte necrosis and conductive system damage, leading to sudden cardiac death and heart failure. Studies have shown that conductive biomaterials can restore cardiac conduction, but cannot facilit…

Chirality is an intrinsic cellular property that describes cell polarization biases along the left-right axis, apicobasal axis, or front-rear axes. Cell chirality plays a significant role in the arrangement of organs in the body as well as …

Endometriosis (EM) is a prevalent and debilitating gynecological disorder primarily affecting women of reproductive age. The diagnosis of EM is historically hampered by delays, owing to the absence of reliable diagnostic and monitoring tech…

Uterosacral ligament suspension (USLS) is a common surgical treatment for pelvic organ prolapse (POP). However, the relatively high failure rate of up to 40% underscores a strong clinical need for complementary treatment strategies, such as…

Cytokine signaling is critical to a range of biological processes including cell development, tissue repair, aging, and immunity. In addition to acting as key signal mediators of the immune system, cytokines can also serve as potent immunot…

Stem cell therapies have made strides toward the efficacious treatment of injured endometrium and the prevention of intrauterine adhesions, or Asherman's syndrome (AS). Despite this progress, they are limited by their risk of tumor formatio…

Biomaterial-mediated inflammation and fibrosis remain a prominent challenge in designing materials to support tissue repair and regeneration. Despite the many biomaterial technologies that have been designed to evade or suppress inflammatio…