{"paper_id":"618e31cd-b1d2-42be-8ce4-1d330d0b2e9e","body_text":"Advanced Hub Main Navigation Menu\nHighly Stable and Bright NIR-II AIE Dots for Fluorescence Imaging-Guided Photothermal Ablation of Endometriosis\nZhihui Huang\nCenter of Obstetrics and Gynecology, Peking University Shenzhen Hospital, Shenzhen, 518036 P. R. China\nInstitute of Obstetrics and Gynecology, Shenzhen PKU-HKUST Medical Center, Shenzhen, 518036 P. R. China\nShenzhen Key Laboratory on Technology for Early Diagnosis of Major Gynecologic Diseases, Shenzhen, 518036 P. R. China\nGuangdong Key Laboratory of Nanomedicine, CAS-HK Joint Lab of Biomaterials, CAS Key Laboratory of Biomedical Imaging Science and System, Institute of Biomedicine and Biotechnology, Shenzhen Institutes of Advanced Technology (SIAT), Chinese Academy of Sciences, Shenzhen, 518055 P. R. China\nSearch for more papers by this authorJinju Lin\nCenter of Obstetrics and Gynecology, Peking University Shenzhen Hospital, Shenzhen, 518036 P. R. China\nInstitute of Obstetrics and Gynecology, Shenzhen PKU-HKUST Medical Center, Shenzhen, 518036 P. R. China\nShenzhen Key Laboratory on Technology for Early Diagnosis of Major Gynecologic Diseases, Shenzhen, 518036 P. R. China\nSearch for more papers by this authorXiaojun Wang\nDepartment of Ophthalmology, Beijing Chaoyang Hospital, Capital Medical University, Beijing, P. R. China\nSearch for more papers by this authorJiqiang Liu\nGuangdong Key Laboratory of Nanomedicine, CAS-HK Joint Lab of Biomaterials, CAS Key Laboratory of Biomedical Imaging Science and System, Institute of Biomedicine and Biotechnology, Shenzhen Institutes of Advanced Technology (SIAT), Chinese Academy of Sciences, Shenzhen, 518055 P. R. China\nSearch for more papers by this authorChunyi Zhou\nChina Railway Lanzhou Group Co., Ltd, Lanzhou, 518024 P. R. China\nSearch for more papers by this authorQingqing Zhang\nStem Cell & Regenerative Medicine Consortium, School of Biomedical Sciences, LKS Faculty of Medicine, The University of Hong Kong, 5/F, Jockey Club Building for Interdisciplinary Research, 5 Sassoon Road, Hong Kong, P. R. China\nCentre for Translational Stem Cell Biology, 17 W Science Park, Hong Kong SAR, P. R. China\nSearch for more papers by this authorPing Gong\nGuangdong Key Laboratory of Nanomedicine, CAS-HK Joint Lab of Biomaterials, CAS Key Laboratory of Biomedical Imaging Science and System, Institute of Biomedicine and Biotechnology, Shenzhen Institutes of Advanced Technology (SIAT), Chinese Academy of Sciences, Shenzhen, 518055 P. R. China\nSearch for more papers by this authorLintao Cai\nGuangdong Key Laboratory of Nanomedicine, CAS-HK Joint Lab of Biomaterials, CAS Key Laboratory of Biomedical Imaging Science and System, Institute of Biomedicine and Biotechnology, Shenzhen Institutes of Advanced Technology (SIAT), Chinese Academy of Sciences, Shenzhen, 518055 P. R. China\nSino-Euro Center of Biomedicine and Health, Shenzhen, 518024 P. R. China\nSearch for more papers by this authorCorresponding Author\nPengfei Zhang\nGuangdong Key Laboratory of Nanomedicine, CAS-HK Joint Lab of Biomaterials, CAS Key Laboratory of Biomedical Imaging Science and System, Institute of Biomedicine and Biotechnology, Shenzhen Institutes of Advanced Technology (SIAT), Chinese Academy of Sciences, Shenzhen, 518055 P. R. China\nE-mail: [email protected]; [email protected]; [email protected]\nSearch for more papers by this authorCorresponding Author\nHe Zhang\nDepartment of Pathophysiology, College of Basic Medical Sciences, Dalian Medical University, Dalian, 116044 P. R. China\nE-mail: [email protected]; [email protected]; [email protected]\nSearch for more papers by this authorCorresponding Author\nHuashan Zhao\nCenter of Obstetrics and Gynecology, Peking University Shenzhen Hospital, Shenzhen, 518036 P. R. China\nInstitute of Obstetrics and Gynecology, Shenzhen PKU-HKUST Medical Center, Shenzhen, 518036 P. R. China\nShenzhen Key Laboratory on Technology for Early Diagnosis of Major Gynecologic Diseases, Shenzhen, 518036 P. R. China\nE-mail: [email protected]; [email protected]; [email protected]\nSearch for more papers by this authorZhihui Huang\nCenter of Obstetrics and Gynecology, Peking University Shenzhen Hospital, Shenzhen, 518036 P. R. China\nInstitute of Obstetrics and Gynecology, Shenzhen PKU-HKUST Medical Center, Shenzhen, 518036 P. R. China\nShenzhen Key Laboratory on Technology for Early Diagnosis of Major Gynecologic Diseases, Shenzhen, 518036 P. R. China\nGuangdong Key Laboratory of Nanomedicine, CAS-HK Joint Lab of Biomaterials, CAS Key Laboratory of Biomedical Imaging Science and System, Institute of Biomedicine and Biotechnology, Shenzhen Institutes of Advanced Technology (SIAT), Chinese Academy of Sciences, Shenzhen, 518055 P. R. China\nSearch for more papers by this authorJinju Lin\nCenter of Obstetrics and Gynecology, Peking University Shenzhen Hospital, Shenzhen, 518036 P. R. China\nInstitute of Obstetrics and Gynecology, Shenzhen PKU-HKUST Medical Center, Shenzhen, 518036 P. R. China\nShenzhen Key Laboratory on Technology for Early Diagnosis of Major Gynecologic Diseases, Shenzhen, 518036 P. R. China\nSearch for more papers by this authorXiaojun Wang\nDepartment of Ophthalmology, Beijing Chaoyang Hospital, Capital Medical University, Beijing, P. R. China\nSearch for more papers by this authorJiqiang Liu\nGuangdong Key Laboratory of Nanomedicine, CAS-HK Joint Lab of Biomaterials, CAS Key Laboratory of Biomedical Imaging Science and System, Institute of Biomedicine and Biotechnology, Shenzhen Institutes of Advanced Technology (SIAT), Chinese Academy of Sciences, Shenzhen, 518055 P. R. China\nSearch for more papers by this authorChunyi Zhou\nChina Railway Lanzhou Group Co., Ltd, Lanzhou, 518024 P. R. China\nSearch for more papers by this authorQingqing Zhang\nStem Cell & Regenerative Medicine Consortium, School of Biomedical Sciences, LKS Faculty of Medicine, The University of Hong Kong, 5/F, Jockey Club Building for Interdisciplinary Research, 5 Sassoon Road, Hong Kong, P. R. China\nCentre for Translational Stem Cell Biology, 17 W Science Park, Hong Kong SAR, P. R. China\nSearch for more papers by this authorPing Gong\nGuangdong Key Laboratory of Nanomedicine, CAS-HK Joint Lab of Biomaterials, CAS Key Laboratory of Biomedical Imaging Science and System, Institute of Biomedicine and Biotechnology, Shenzhen Institutes of Advanced Technology (SIAT), Chinese Academy of Sciences, Shenzhen, 518055 P. R. China\nSearch for more papers by this authorLintao Cai\nGuangdong Key Laboratory of Nanomedicine, CAS-HK Joint Lab of Biomaterials, CAS Key Laboratory of Biomedical Imaging Science and System, Institute of Biomedicine and Biotechnology, Shenzhen Institutes of Advanced Technology (SIAT), Chinese Academy of Sciences, Shenzhen, 518055 P. R. China\nSino-Euro Center of Biomedicine and Health, Shenzhen, 518024 P. R. China\nSearch for more papers by this authorCorresponding Author\nPengfei Zhang\nGuangdong Key Laboratory of Nanomedicine, CAS-HK Joint Lab of Biomaterials, CAS Key Laboratory of Biomedical Imaging Science and System, Institute of Biomedicine and Biotechnology, Shenzhen Institutes of Advanced Technology (SIAT), Chinese Academy of Sciences, Shenzhen, 518055 P. R. China\nE-mail: [email protected]; [email protected]; [email protected]\nSearch for more papers by this authorCorresponding Author\nHe Zhang\nDepartment of Pathophysiology, College of Basic Medical Sciences, Dalian Medical University, Dalian, 116044 P. R. China\nE-mail: [email protected]; [email protected]; [email protected]\nSearch for more papers by this authorCorresponding Author\nHuashan Zhao\nCenter of Obstetrics and Gynecology, Peking University Shenzhen Hospital, Shenzhen, 518036 P. R. China\nInstitute of Obstetrics and Gynecology, Shenzhen PKU-HKUST Medical Center, Shenzhen, 518036 P. R. China\nShenzhen Key Laboratory on Technology for Early Diagnosis of Major Gynecologic Diseases, Shenzhen, 518036 P. R. China\nE-mail: [email protected]; [email protected]; [email protected]\nSearch for more papers by this authorAbstract\nEndometriosis (EM) is a non-cancerous disease that exhibits certain tumor-like properties. While hormonal therapies and surgical excision are standard treatments with proven efficacy in alleviating EM symptoms, they are often accompanied by side effects and a high risk of recurrence after surgery. Therefore, there is an urgent need for non-invasive imaging and therapeutic strategies to address this condition effectively. In this study, second-window near-infrared (NIR-II, 1000–1700 nm) fluorescence imaging is employed, which offers superior spatial resolution, deeper tissue penetration, reduced light scattering, and minimal tissue autofluorescence, to identify EM lesions using aggregation-induced emission luminogen dots (AIE dots). The AIE dots exhibited excellent photothermal properties, achieving a photothermal conversion efficiency of 40%. AIE dots efficiently accumulate at the lesion site through the enhanced permeability and retention (EPR) effect and rapidly heat up to 50 °C under 808 nm laser irradiation, facilitating the effective ablation of EM lesions. Histological analysis, including hematoxylin and eosin (HE) staining and immunofluorescence staining, confirmed notable reduction of the EM lesions, indicating effective inhibition of lesion progression. This strategy highlights the potential of NIR-II fluorescence-guided photothermal therapy as a promising non-invasive approach for both the diagnosis and treatment of EM.\nConflict of Interest\nThe authors declare no conflict of interest.\nData Availability Statement\nThe data that support the findings of this study are available from the corresponding author upon reasonable request.\nSupporting Information\n| Filename | Description |\n|---|---|\n| adhm202501464-sup-0001-SuppMat.docx11.2 MB | Supporting Information |\nPlease note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.\nReferences\n- 1L. C. Giudice, L. C. Kao, Lancet 2004, 364, 1789.\n- 2A. W. Horne, S. A. Missmer, BMJ 2022, 379, 070750.\n- 3a) S. Vannuccini, S. Clemenza, M. Rossi, F. Petraglia, Rev Endocr Metab Disord 2022, 23, 333; b) L. K. 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