Detection of peritoneal endometriotic lesions by autofluorescence laparoscopy

Olaf Buchweitz, Buchweitz O, Staebler A, Annette Staebler, Tio J, Joke Tio, Ludwig Kiesel, Kiesel L
American journal of obstetrics and gynecology · 2006 · vol. 195(4) , pp. 949–954 · doi:10.1016/j.ajog.2006.02.044 · PMID:16677595 · W2089346856
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Autofluorescence laparoscopy effectively detects peritoneal endometriotic lesions, offering a potential improvement in diagnosis during laparoscopic surgery.

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Abstract

ObjectiveThis study was undertaken to evaluate the feasibility of autofluorescence laparoscopy in the diagnosis of endometriotic lesions.Study designProspective analysis of 83 consecutive patients undergoing laparoscopy for suspected endometriosis under white light illumination and autofluorescence diagnosis. The study measured total number of endometriotic lesions diagnosed under white light illumination and with autofluorescence diagnosis.ResultsThe biopsy-based sensitivity of white light diagnosis alone and white light illumination and autofluorescence for detecting nonpigmented peritoneal endometriotic lesions was 65% compared with 92% (1.42-fold increase). The corresponding specificity was 68% as opposed to 84%. Occult areas of endometriosis were discovered using autofluorescence diagnosis. Statistical analysis was performed with chi2 test and McNemar test.ConclusionCombination of white light illumination and autofluorescence is significantly superior to white light illumination alone in detecting nonpigmented endometriotic lesions. Autofluorescence diagnosis of nonpigmented endometriotic lesions may become an alternative to fluorescence diagnosis after application of 5-aminolevulinic acid, especially because of no side effects.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Laparoscopy Peritoneal Diseases Adult Aminolevulinic Acid Endometriosis Female Fluorescence Humans Laparoscopy Peritoneal Diseases Sensitivity and Specificity

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Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

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