Expression of vascular endothelial growth factor-A and its receptor-1 in a luteal endometrium in patients with repeated in vitro fertilization failure

Byung Chul Jee, Chang Suk Suh, Ki Chul Kim, Won Don Lee, Haeryoung Kim, Seok Hyun Kim, Seoul National University College of Medicine Assisted Reproductive Technology (SMART) Study Group
Fertility and sterility · 2008 · vol. 91(2) , pp. 528–534 · doi:10.1016/j.fertnstert.2007.11.081 · PMID:18295763 · W1983980559
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This study investigated the expression of vascular endothelial growth factor-A and its receptor-1 in the luteal endometrium of patients experiencing repeated in vitro fertilization failure.

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Abstract

OBJECTIVE: To investigate temporal and spatial relationships of vascular endothelial growth factor (VEGF)-A and its receptor (VEGFR-1) expression in a luteal endometrium obtained from patients with repeated IVF failure. DESIGN: Immunohistochemical study. SETTING: University hospital. PATIENT(S): Thirty-three regular-cycling infertile women (mean age, 34.4 years) who experienced three or more failed IVF cycles (range, 3-14 cycles). INTERVENTION(S): Endometrial samplings by silastic suction curette in the luteal phase of a spontaneous unmedicated cycle. MAIN OUTCOME MEASURE(S): Immunohistochemical intensity scoring after staining by monoclonal anti-VEGF-A and polyclonal anti-VEGFR-1. Microvascular density determined after staining by monoclonal anti-CD31 antibody. The data were compared in three phases; early (cycle day [CD]16-19) (n = 12), mid- (CD20-24) (n = 13), and late luteal phase (CD25-27) (n = 8). RESULT(S): Expression of VEGF-A tended to be lower in midluteal endometrium at epithelial, stromal, and endothelial cells. Expression of VEGFR-1 at epithelial cells was highest in midluteal endometrium, but VEGFR-1 at stroma and endothelium and microvascular density continuously decreased throughout luteal-phase endometrium. CONCLUSION(S): In contrast to previous reports, VEGF-A expression was not highest in the midluteal phase in repeated IVF failure patients who had no apparent endometrial pathology. Further research is needed to determine whether different VEGF-A expression patterns in the luteal phase contribute to repeated IVF failure.

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MeSH descriptors

Endometrium Fertilization in Vitro Luteal Phase Vascular Endothelial Growth Factor A Vascular Endothelial Growth Factor Receptor-1 Adult Capillaries Capillaries Capillaries Endometrium Endometrium Endothelial Cells Endothelial Cells Endothelial Cells Epithelial Cells Epithelial Cells Female Humans Immunohistochemistry Luteal Phase

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