Expression of vascular endothelial growth factor-A and its receptor-1 in a luteal endometrium in patients with repeated in vitro fertilization failure

Byung Chul Jee, Chang Suk Suh, Ki Chul Kim, Won Don Lee, Haeryoung Kim, Seok Hyun Kim
In: Fertility and Sterility · 2008 · vol. 91(2) , pp. 528–534 · doi:10.1016/j.fertnstert.2007.11.081 · PMID:18295763 · W1983980559
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This study investigated the expression of vascular endothelial growth factor-A and its receptor-1 in the luteal endometrium of patients experiencing repeated in vitro fertilization failure.

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Abstract

ObjectiveTo investigate temporal and spatial relationships of vascular endothelial growth factor (VEGF)-A and its receptor (VEGFR-1) expression in a luteal endometrium obtained from patients with repeated IVF failure.DesignImmunohistochemical study.SettingUniversity hospital.Patient(s)Thirty-three regular-cycling infertile women (mean age, 34.4 years) who experienced three or more failed IVF cycles (range, 3-14 cycles).Intervention(s)Endometrial samplings by silastic suction curette in the luteal phase of a spontaneous unmedicated cycle.Main outcome measure(s)Immunohistochemical intensity scoring after staining by monoclonal anti-VEGF-A and polyclonal anti-VEGFR-1. Microvascular density determined after staining by monoclonal anti-CD31 antibody. The data were compared in three phases; early (cycle day [CD]16-19) (n = 12), mid- (CD20-24) (n = 13), and late luteal phase (CD25-27) (n = 8).Result(s)Expression of VEGF-A tended to be lower in midluteal endometrium at epithelial, stromal, and endothelial cells. Expression of VEGFR-1 at epithelial cells was highest in midluteal endometrium, but VEGFR-1 at stroma and endothelium and microvascular density continuously decreased throughout luteal-phase endometrium.Conclusion(s)In contrast to previous reports, VEGF-A expression was not highest in the midluteal phase in repeated IVF failure patients who had no apparent endometrial pathology. Further research is needed to determine whether different VEGF-A expression patterns in the luteal phase contribute to repeated IVF failure.

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