Transcript profile and localization of Wnt signaling-related molecules in human endometrium

Cheng CW, Ching-wen Cheng, S. K. Smith, Stephen K Smith, D. Stephen Charnock-jones, D. Stephen Charnock‐Jones
Fertility and sterility · 2007 · vol. 90(1) , pp. 201–204 · doi:10.1016/j.fertnstert.2007.05.077 · PMID:17889861 · W1982242727
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This study examined the gene expression patterns and cellular locations of molecules involved in Wnt signaling within the human endometrium.

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Abstract

The mRNAs encoding several Wnt ligands, Frizzled receptors, and Wnt antagonists were detected in human endometrium, including SFRP1; the levels of SFRP1 mRNA were higher in the proliferative phase of the menstrual cycle and increased in endometriotic tissue compared with control eutopic endometrium, and they were detected in both glandular and stromal cells but were more abundant in the stroma. Our results suggest that Wnt signaling could function in normal endometrial physiology and the the Wnt signalling inhibitor SFRP1 might play a role in endometrial growth and endometriosis development.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Endometrium Gene Expression Profiling Gene Expression Profiling Gene Expression Profiling RNA, Messenger Signal Transduction Wnt Proteins Adult Adult Endometriosis Endometriosis Endometriosis Endometrium Endometrium Endometrium England England Female Female

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