Three-dimensional power Doppler sonography of the (sub)endometrium and angiogenic cytokine concentrations

J. Siemer, Helge Binder, C. Willeke, C. Dorn, J. Reinsberg, Rolf Fimmers, H. van der Ven, RL Schild
In: Reproductive BioMedicine Online · 2008 · vol. 17(2) , pp. 249–258 · doi:10.1016/s1472-6483(10)60202-7 · PMID:18682000 · W2011271162
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This study used three-dimensional power Doppler sonography to analyze the (sub)endometrium and its correlation with angiogenic cytokine concentrations in women.

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Abstract

The aim of this study was to determine the correlation between three-dimensional power Doppler sonography (3D-PDS) of the (sub)endometrium and concentrations of angiogenic cytokines in patients attending an IVF programme. A total of 42 patients was included in a prospective, non-randomized clinical study. 3D-PDS of the (sub)endometrium was performed on the day of oocyte aspiration, with and without contrast agent. Quantitative assessment included the following 3D Doppler parameters: vascularization index, flow intensity, and vascularization flow index. On the same day, concentrations of oestradiol (serum only), vascular endothelial growth factor (VEGF), insulin-like growth factor (IGF) 1, IGF-binding protein 3 (IGFBP-3) and leptin were determined in the serum and in the follicular fluid. All 3D-PDS indices were significantly higher with contrast enhancement (P < 0.05). Follicular fluid concentrations of VEGF and IGFBP-3, as well as serum concentrations of leptin, showed significant P-values when correlated with (sub)endometrial Doppler indices. A weak linear dependency appeared between flow intensity and VEGF and leptin. Furthermore, weak dependencies were apparent between 3D Doppler parameters and high follicular fluid concentrations of VEGF and IGFBP-3. It is concluded that there is only little evidence for an association between (sub)endometrial Doppler indices as assessed by 3D-PDS and concentrations of angiogenic cytokines.

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