Three-dimensional power Doppler sonography of the (sub)endometrium and angiogenic cytokine concentrations

J. Siemer, H. Binder, Helge Binder, C. Willeke, C. Dorn, J. Reinsberg, R Fimmers, Rolf Fimmers, H. van der Ven, R L Schild, RL Schild
Reproductive BioMedicine Online · 2008 · vol. 17(2) , pp. 249–258 · doi:10.1016/s1472-6483(10)60202-7 · PMID:18682000 · W2011271162
Non-randomised trial OA: bronze CC0
🔓 Open OA copy View on OpenAlex View on PubMed View at publisher
⚙ AI-generated summary by gemini-2.5-flash-lite, 2026-06-13 ⓘ

This study used three-dimensional power Doppler sonography to analyze the (sub)endometrium and its correlation with angiogenic cytokine concentrations in women.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

Abstract

The aim of this study was to determine the correlation between three-dimensional power Doppler sonography (3D-PDS) of the (sub)endometrium and concentrations of angiogenic cytokines in patients attending an IVF programme. A total of 42 patients was included in a prospective, non-randomized clinical study. 3D-PDS of the (sub)endometrium was performed on the day of oocyte aspiration, with and without contrast agent. Quantitative assessment included the following 3D Doppler parameters: vascularization index, flow intensity, and vascularization flow index. On the same day, concentrations of oestradiol (serum only), vascular endothelial growth factor (VEGF), insulin-like growth factor (IGF) 1, IGF-binding protein 3 (IGFBP-3) and leptin were determined in the serum and in the follicular fluid. All 3D-PDS indices were significantly higher with contrast enhancement (P < 0.05). Follicular fluid concentrations of VEGF and IGFBP-3, as well as serum concentrations of leptin, showed significant P-values when correlated with (sub)endometrial Doppler indices. A weak linear dependency appeared between flow intensity and VEGF and leptin. Furthermore, weak dependencies were apparent between 3D Doppler parameters and high follicular fluid concentrations of VEGF and IGFBP-3. It is concluded that there is only little evidence for an association between (sub)endometrial Doppler indices as assessed by 3D-PDS and concentrations of angiogenic cytokines.

My notes (saved in your browser only)

MeSH descriptors

Angiogenic Proteins Cytokines Endometrium Imaging, Three-Dimensional Imaging, Three-Dimensional Ultrasonography, Doppler Adolescent Adult Angiogenic Proteins Cytokines Cytokines Endometrium Endometrium Estradiol Estradiol Female Fertilization in Vitro Fertilization in Vitro Follicular Fluid Follicular Fluid

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (61)

Source provenance

openalex
last seen: 2026-06-10T17:14:06.276822+00:00
pubmed
last seen: 2026-10-08T21:05:36.063128+00:00
License: CC0 · commercial use OK