Regulation of human endometrial function: mechanisms relevant to uterine bleeding

Hilary O D Critchley, Hilary Critchley, Rodney W Kelly, R.W. Kelly, David T Baird, Robert Brenner, Robert M Brenner
Reproductive biology and endocrinology : RB&E · 2006 · vol. 4(S1) , pp. S5 · doi:10.1186/1477-7827-4-s1-s5 · PMID:17118169 · PMC1775065 · W1652282237
review OA: gold CC0 ⤵ 12 in-corpus citations
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⚙ AI-generated summary by claude@2026-06, 2026-06-08 ⓘ

This review examines the mechanisms of endometrial function after progesterone withdrawal that lead to uterine bleeding, relevant for understanding and treating abnormal bleeding and developing new contraceptives.

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Abstract

This review focuses on the complex events that occur in the endometrium after progesterone is withdrawn (or blocked) and menstrual bleeding ensues. A detailed understanding of these local mechanisms will enhance our knowledge of disturbed endometrial/uterine function--including problems with excessively heavy menstrual bleeding, endometriosis and breakthrough bleeding with progestin only contraception. The development of novel strategies to manage these clinically significant problems depends on such new understanding as does the development of new contraceptives which avoid the endometrial side effect of breakthrough bleeding.

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Condition tags

endometriosis

MeSH descriptors

Endometrium Uterine Hemorrhage Cell Hypoxia Cell Hypoxia Endometrium Endometrium Endometrium Female Gene Expression Regulation Gene Expression Regulation Gonadal Steroid Hormones Gonadal Steroid Hormones Humans Matrix Metalloproteinases Matrix Metalloproteinases Matrix Metalloproteinases Models, Biological Progesterone Progesterone Receptors, Cytoplasmic and Nuclear

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Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (100)

Cited by (12)

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europepmc
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License: CC0 · commercial use OK