The Apoptotic, Angiogenic and Cell Proliferation Genes CD63, S100A6 e GNB2L1 are Altered in Patients with Endometriosis

Valéria A. Gomes, Valéria Aguiar Gomes, Camila de Moraes Bonocher, Júlio César Rosa e Silva, Júlio César Rosa-E-Silva, Cláudia Cristina Paro de Paz, Rui Alberto Ferriani, Juliana Meola
Revista brasileira de ginecologia e obstetricia : revista da Federacao Brasileira das Sociedades de Ginecologia e Obstetricia · 2018 · vol. 40(10) , pp. 606–613 · doi:10.1055/s-0038-1673364 · PMID:30352458 · W2897177803
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⚙ AI-generated summary by claude@2026-06, 2026-06-08 ⓘ

CD63, S100A6, and GNB2L1 gene expression was increased in ectopic endometriosis implants compared to eutopic endometrium, suggesting their involvement in endometriosis pathogenesis.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-08 ⓘ

This case-control study measured mRNA expression levels of the apoptotic/angiogenic/proliferation-related genes CD63, S100A6, and GNB2L1 using qRT-PCR in paired samples of eutopic endometrium and ectopic endometriotic implants (peritoneal and ovarian) from 40 women with endometriosis, and paired endometrial biopsies from 15 fertile, healthy control women, sampled in proliferative versus secretory menstrual cycle phases. Transcript levels of CD63, S100A6, and GNB2L1 were higher in ectopic implants than in eutopic endometrium in women with endometriosis and also when compared to eutopic endometrium in controls, with the difference observed regardless of menstrual phase. The authors interpret these gene expression changes in terms of pathways involving inhibition of apoptosis, angiogenesis, and cell proliferation, though a key limitation is that the study is limited to gene transcript measurement rather than functional assays of these mechanisms. This paper is centrally about endometriosis — it reports altered expression of CD63, S100A6, and GNB2L1 in eutopic versus ectopic endometrial tissues from patients with endometriosis.

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Abstract

Objective The aim of the present study was to analyze the expression of the CD63, S100A6, and GNB2L1genes, which participate in mechanisms related to the complex pathophysiology of endometriosis. Methods A case-control study was conducted with 40 women who were diagnosed with endometriosis, and 15 fertile and healthy women. Paired samples of eutopic endometrium and endometriotic lesions (peritoneal and ovarian endometriotic implants) were obtained from the women with endometriosis in the proliferative (n = 20) or secretory phases (n = 20) of the menstrual cycle. As controls, paired endometrial biopsy samples were collected from the healthy women in the proliferative (n = 15) and secretory (n = 15) phases of the same menstrual cycle. We analyzed the expression levels of the CD63, S100A6, and GNB2L1 genes by real-time polymerase chain reaction. Results An increase in CD63, S100A6, and GNB2L1 gene transcript levels was observed in the ectopic implants compared with the eutopic endometrium of the women with and without endometriosis, regardless of the phase of the menstrual cycle. Conclusion These findings suggest that the CD63, S100A6, and GNB2L1 genes may be involved in the pathogenesis of endometriosis, since they participate in mechanisms such as inhibition of apoptosis, angiogenesis and cell proliferation, which lead to the loss of cell homeostasis in the ectopic endometrium, thus contributing to the implantation and survival of the tissue in the extrauterine environment.

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Condition tags

endometriosis

MeSH descriptors

Apoptosis Cell Cycle Proteins Cell Proliferation Endometriosis Endometriosis Neoplasm Proteins Neovascularization, Pathologic Receptors for Activated C Kinase S100 Calcium Binding Protein A6 Tetraspanin 30 Adult Apoptosis Case-Control Studies Cell Cycle Proteins Cell Proliferation Endometriosis Female Gene Expression Humans Neoplasm Proteins

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