Effect of S100A6 over‐expression on β‐catenin in endometriosis

Liu Z, Zequn Liu, Xiaoling Zhang, Zhang X, Meihong Chen, Chen M, Qing Cao, Cao Q, Huang D, Donghua Huang
Journal of Obstetrics and Gynaecology Research · 2015 · vol. 41(9) , pp. 1457–1462 · doi:10.1111/jog.12729 · PMID:26044826 · W1590271901
article OA: closed CC0 ⤵ 2 in-corpus citations
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Over-expression of S100A6 in human endometrial stromal cells promoted β-catenin expression at both RNA and protein levels.

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Abstract

AIM: S100A6 is over-expressed in several human tumors, including pancreatic carcinoma, malignant fibrous histiocytoma, breast, colon, and gastric carcinoma, but little is known about the role of S100A6 in endometriosis. The aim of the present study was to investigate the effect of S100A6 over-expression on β-catenin in endometrial stromal cells. METHODS: Endometrial stromal cells were transfected with an hS100A6-expressing recombinant lentivirus construct. The expression of β-catenin was assessed using western blot and reverse transcription-polymerase chain reaction. RESULTS: S100A6 over-expression promoted β-catenin expression at the RNA and protein levels, in endometrial stromal cells. CONCLUSIONS: S100A6 induces expression of β-catenin in endometrial stromal cells.

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Condition tags

endometriosis

MeSH descriptors

beta Catenin Cell Cycle Proteins Endometriosis Endometrium Ovarian Diseases S100 Proteins Stromal Cells Adult beta Catenin beta Catenin Cell Cycle Proteins Cell Cycle Proteins Cells, Cultured Endometriosis Endometriosis Endometriosis Endometrium Endometrium Female Humans

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License: CC0 · commercial use OK