The Importance of Serum Prolidase Activity in Endometriosis

P Karlı, Mukaddes Demir Dural, Fatma Devran Bıldırcın, Ayşe Özdemir
In: Journal of Clinical and Experimental Investigations · 2019 · vol. 10(4) , pp. em00729 · doi:10.5799/jcei/5903 · W2970901604
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⚙ AI-generated summary by claude@2026-06, 2026-06-07 ⓘ

Serum prolidase activity was significantly higher in stage 4 endometriosis patients compared to controls, suggesting its role in lesion development and progression.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-07 ⓘ

This prospective study measured serum prolidase activity as a marker of extracellular matrix/collagen turnover in 37 reproductive-age patients with suspected endometriosis and pelvic pain, dysmenorrhea, and/or infertility, comparing 22 endometriosis cases confirmed by intraoperative/pathology assessment with 15 controls who had no endometriosis pathology or benign gynecologic diagnoses. The authors found no overall difference in serum prolidase levels between early-to-moderate (ASRM stages 1–3) endometriosis patients and controls, but serum prolidase activity was significantly higher in stage 4 endometriosis patients versus controls. They also reported that CA-125 differed significantly between stage 4 and stages 1–3 within the endometriosis group, while prolidase did not for stages 1–3 vs controls (with the main limitation being the small, single-center sample and stage imbalance, especially the small number of early-stage cases). This paper is centrally about endometriosis — it evaluates serum prolidase activity and its association with disease stage, progression, and infertility-related mechanisms.

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Abstract

Objective: In this study, our objective was to evaluate the abnormal collagen destruction and turnover and the prolidase activity in the etiopathogenesis of endometriosis, which may deteriorate the collagenous structure of exracellular matrix (ECM). Materials and Methods: For the assessment of the prolidase activity, venous blood samples were obtained from 37 patients, who had applied to the outpatient department of the Medical Faculty at Ondokuz Mayıs University with complaints of pelvic pain, dysmenorrhea and infertility between October 1st, 2011 and February 15th, 2012, underwent clinical and ultrasonographic examination, prediagnosed with endometriosis, and scheduled for laparoscopy or laparotomy. A total of 22 patients, who were diagnosed with endometriosis via intraoperative exploration and/or pathological examination, constituted the study group and the remaining 15 patients, who did not have any pathological finding or were diagnosed with a benign disease except for endometriosis, constituted the control group. Serum samples obtained from all patients were first centrifuged and then stored in a freezer at -70 C until the time of analysis. During the analysis, the prolidase activity was measured following the necessary biochemical enzymatic processing. Results: We found a statistically significant difference between stage 4 and stage 1,2,3 patients in the study group regarding the CA 125 levels (p=0.018). On the other hand, there was no statistically significant difference between stage 1,2,3 patients in the study group and the control group for serum prolidase levels (p=0.778). There was a statistically significant difference between stage 4 endometriosis patients in the study group and the control group considering the serum prolidase levels (p=0.026). Conclusion: We conclude that serum prolidase activity has a critical function in the development of the endometriotic lesions. In endometriosis patients, the increase in the serum prolidase activity may play an important role in the progress to more advanced stages and in the development of infertility.

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Condition tags

endometriosisdysmenorrheainfertility

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