Gynecologic diseases get their genes

Martin M Matzuk
Nature medicine · 2005 · vol. 11(1) , pp. 24–26 · doi:10.1038/nm0105-24 · PMID:15635441 · W2001524362
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New mouse models of ovarian cancer and endometriosis were created, defining the genetic relationship between these two gynecologic diseases.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-09 · read from full text ⓘ

This paper describes the creation of new mouse models of ovarian cancer and endometriosis to elucidate the genetic relationship between these two gynecologic diseases. At a high level, it focuses on model development and the genetic links implied by those models rather than population-based human sampling or a detailed experimental protocol. The key finding presented is that these models can be used to define and compare the genetic relationships between ovarian cancer and endometriosis. The caveat is that the content provided here is only a brief preview and the article itself is paywalled, limiting access to full methodological and limitation details. This paper is centrally about endometriosis—mouse model development to define its genetic relationship with ovarian cancer.

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New mouse models of ovarian cancer and endometriosis have been created, defining the genetic relationship between these two gynecologic diseases (pages 63–70). This is a preview of subscription content, access via your institution Access options Subscribe to this journal Receive 12 print issues and online access 251,40 € per year only 20,95 € per issue Buy this article - Purchase on SpringerLink - Instant access to the full article PDF. 39,95 € Prices may be subject to local taxes which are calculated during checkout References Matzuk, M.M. & Lamb, D.J. Nat. Med. 8 Suppl 1, S41–S49 (2002). Matzuk, M.M., Finegold, M.J., Su, J.-G.J., Hsueh, A.J.W. & Bradley, A. Nature 360, 313–319 (1992). Dinulescu, D. et al. Nat. Med. 10, 63–70 (2005). Giudice, L.C. & Kao, L.C. Lancet 364, 1789–1799 (2004). Gemignani, M.L. et al. Gynecol. Oncol. 90, 378–381 (2003). Connolly, D.C. et al. Cancer Res. 63, 1389–1397 (2003). Orsulic, S. et al. Cancer Cell 1, 53–62 (2002). Flesken-Nikitin, A., Choi, K.C., Eng, J.P., Shmidt, E.N. & Nikitin, A.Y. Cancer Res. 63, 3459–3463 (2003). Skilling, J.S., Sood, A., Niemann, T., Lager, D.J. & Buller, R.E. Oncogene 13, 117–123 (1996). Sato, N. et al. Cancer Res. 60, 7052–7056 (2000). Wu, R., Zhai, Y., Fearon, E.R. & Cho, K.R. Cancer Res. 61, 8247–8255 (2001). Author information Authors and Affiliations Rights and permissions About this article Cite this article Matzuk, M. Gynecologic diseases get their genes. Nat Med 11, 24–26 (2005). https://doi.org/10.1038/nm0105-24 Published: Issue date: DOI: https://doi.org/10.1038/nm0105-24 This article is cited by - Immunobiology of human mucin 1 in a preclinical ovarian tumor model Oncogene (2013) - The biology of infertility: research advances and clinical challenges Nature Medicine (2008)

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Condition tags

mesh:D004715

MeSH descriptors

Endometriosis Ovarian Neoplasms Animals Disease Models, Animal Endometriosis Endometriosis Endometriosis Female Mice Ovarian Neoplasms Ovarian Neoplasms Ovarian Neoplasms Protein Tyrosine Phosphatases Protein Tyrosine Phosphatases PTEN Phosphohydrolase ras Proteins ras Proteins Tumor Suppressor Proteins Tumor Suppressor Proteins

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

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