Endometriosis and Cancer: Prevention and Diagnosis

Silvia Vannuccini, Sara Clemenza, Felice Petraglia
In: ISGE Series · 2020 · pp. 133–147 · doi:10.1007/978-3-030-57866-4_13 · W3113330275
book-chapter OA: closed CC0 ⤵ 1 in-corpus citation
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⚙ AI-generated summary by claude@2026-06+body, 2026-06-07 ⓘ

Endometriosis, a benign reproductive disease, shares cancer-like cellular behaviors and potential genetic links, but its role as a premalignant condition for ovarian cancers remains unclear.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-07 ⓘ

This paper reviews evidence and gaps linking endometriosis to cancer, focusing on prevention and diagnosis, with particular attention to endometriosis-associated ovarian cancer (EAOC) and its heterogeneous histologic types. It summarizes shared cancer-like properties (evasion of apoptosis, proliferation and migration, implantation, neovascularization, immune-evasive microenvironment) and reports suggested genetic links involving driver mutations such as PIK3CA, KRAS, and ARID1A, while noting that the molecular mechanisms are not fully understood. For clinical translation, it emphasizes that results on the endometriosis–cancer association are controversial and that there are no conclusive data showing that specific screening protocols or prophylactic removal of endometriosis lesions reduce EAOC risk. This paper is centrally about endometriosis—specifically the reviewed relationship between endometriosis and ovarian cancer and implications for prevention and diagnosis.

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endometriosis

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last seen: 2026-06-10T17:14:06.276822+00:00
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