Clinical implication for endometriosis associated with ovarian cancer

Pao-Ling Torng; Pao‐Ling Torng

doi:10.1016/j.gmit.2017.08.003

Clinical implication for endometriosis associated with ovarian cancer

Pao-Ling Torng, Pao‐Ling Torng

Gynecology and minimally invasive therapy · 2017 · vol. 6(4) , pp. 152–156 · doi:10.1016/j.gmit.2017.08.003 · PMID:30254904 · PMC6135201 · W2752656365

review OA: gold CC0 ⤵ 16 in-corpus citations

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This review examines the epidemiological, molecular, and clinical data on endometriosis-associated ovarian cancer, identifying specific histological subtypes, molecular aberrations, and sonographic features relevant to its development and management.

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Abstract

We reviewed current literature regarding the association of endometriosis and epithelial ovarian cancer based on epidemiology studies, molecular researches and clinical observations. Our methods include a review of literature research of MEDLINE, PubMed, Cochrane Library of Systematic Reviews and reference search in selected papers. The life time risk of epithelial ovarian cancer in women with endometriosis is low, yet there might be a cluster of individuals who have higher risk of developing epithelial ovarian cancer from endometriosis. Endometriosis associated ovarian cancer (EAOC) is predominant in particular histological subtypes of epithelial ovarian carcinoma and are related to some specific molecular aberrations. Clinical observations showed age as an important variable to the development of EAOC. Rapid growth of tumor and solid components in sonography are key features to detect malignant transformation of endometriosis. Evidence is not clear about prophylactic oophorectomy in preventing EAOC in patients with endometriosis. This review provided rationale data for identifying, monitoring, counseling and management of women with endometriosis who are potentially high risk for malignant transformation.

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endometriosis

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References (42)

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Clinical analysis of ovarian epithelial carcinoma with coexisting pelvic endometriosis via openalex
Clinical Characteristics of Patients in Japan with Ovarian Cancer Presumably Arising from Ovarian Endometrioma via openalex
Comparison of clinical outcomes of patients with clear cell and endometrioid ovarian cancer associated with endometriosis to papillary serous carcinoma of the ovary via openalex
Distinct β-Catenin and PIK3CA Mutation Profiles in Endometriosis-Associated Ovarian Endometrioid and Clear Cell Carcinomas via openalex
Does the Presence of Endometriosis Affect Prognosis of Ovarian Cancer? via openalex
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In vitro fertilization, endometriosis, nulliparity and ovarian cancer risk via openalex
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Cited by (16)

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License: CC0 · commercial use OK

[1] Assessing Ovarian Cancer Risk When Considering Elective Oophorectomy at the Time of Hysterectomy via openalex

[2] Clinical analysis of ovarian epithelial carcinoma with coexisting pelvic endometriosis via openalex

[3] Clinical Characteristics of Patients in Japan with Ovarian Cancer Presumably Arising from Ovarian Endometrioma via openalex

[4] Comparison of clinical outcomes of patients with clear cell and endometrioid ovarian cancer associated with endometriosis to papillary serous carcinoma of the ovary via openalex

[5] Distinct β-Catenin and PIK3CA Mutation Profiles in Endometriosis-Associated Ovarian Endometrioid and Clear Cell Carcinomas via openalex

[6] Does the Presence of Endometriosis Affect Prognosis of Ovarian Cancer? via openalex

[7] ENDOMETRIAL CARCINOMA OF THE OVARY, ARISING IN ENDOMETRIAL TISSUE IN THAT ORGAN via openalex

[8] Endometriosis via openalex

[9] Endometriosis and ovarian cancer: potential benefits and harms of screening and risk-reducing surgery via openalex

[10] Endometriosis and risks for ovarian, endometrial and breast cancers: A nationwide cohort study via openalex

[11] EPIDEMIOLOGY OF ENDOMETRIOSIS via openalex

[12] Evidence of a genetic link between endometriosis and ovarian cancer via openalex

[13] <i>ARID1A</i> Mutations in Endometriosis-Associated Ovarian Carcinomas via openalex

[14] Identification of multiple pathways involved in the malignant transformation of endometriosis (Review) via openalex

[15] Increased risk for ovarian cancer and borderline ovarian tumours in subfertile women with endometriosis via openalex

[16] In vitro fertilization, endometriosis, nulliparity and ovarian cancer risk via openalex

[17] <i>PIK3CA</i> mutation is an early event in the development of endometriosis‐associated ovarian clear cell adenocarcinoma via openalex

[18] Is early age at menarche a risk factor for endometriosis? A systematic review and meta-analysis of case-control studies via openalex

[19] Loss of heterozygosity on 10q23.3 and mutation of the tumor suppressor gene PTEN in benign endometrial cyst of the ovary: possible sequence progression from benign endometrial cyst to endometrioid carcinoma and clear cell carcinoma of the ovary. via openalex

[20] Multifocal endometriotic lesions associated with cancer are clonal and carry a high mutation burden via openalex

[21] Oral contraceptives and risk of endometriosis: a systematic review and meta-analysis via openalex

[22] Patterns of Loss of Heterozygosity at 10q23.3 and Microsatellite Instability in Endometriosis, Atypical Endometriosis, and Ovarian Carcinoma Arising in Association With Endometriosis via openalex

[23] Predictive factors for the presence of malignant transformation of pelvic endometriosis via openalex

[24] Removal of normal ovaries in women under age 51 at the time of hysterectomy via openalex

[25] Risk and prognosis of ovarian cancer in women with endometriosis: a meta-analysis via openalex

[26] Shared genetics underlying epidemiological association between endometriosis and ovarian cancer via openalex

[27] Shared genetics underlying epidemiological association between endometriosis and ovarian cancer via openalex

[28] The <i>ARID1A</i> pathway in ovarian clear cell and endometrioid carcinoma, contiguous endometriosis, and benign endometriosis via openalex

[29] The 'incessant menstruation' hypothesis: a mechanistic ovarian cancer model with implications for prevention via openalex

[30] The relation between endometriosis and ovarian cancer – a review via openalex

[31] The Risk of Epithelial Ovarian Cancer of Women With Endometriosis May be Varied Greatly if Diagnostic Criteria Are Different via openalex

[32] W6638686170 via openalex

[33] W2053988163 via openalex

[34] W2024474882 via openalex

[35] W2068085420 via openalex

[36] W2125681453 via openalex

[37] W2127886272 via openalex

[38] W2169959178 via openalex

[39] W1892941594 via openalex

[40] W2328462619 via openalex

[41] W2592289577 via openalex

[42] W2030404955 via openalex