Clinical Characteristics of Patients in Japan with Ovarian Cancer Presumably Arising from Ovarian Endometrioma

Fuminori Taniguchi, Tasuku Harada, Hiroshi Kobayashi, Kunihiko Hayashi, Mikio Momoeda, Naoki Terakawa
Gynecologic and obstetric investigation · 2014 · vol. 77(2) , pp. 104–110 · doi:10.1159/000357819 · PMID:24503885 · W2020045892
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⚙ AI-generated summary by claude@2026-06, 2026-06-09 ⓘ

This retrospective study of 33 Japanese patients found that early detection of ovarian cancer arising from endometrioma requires assessing mural nodules and rapid tumor growth, with most patients being premenopausal and diagnosed with stage I clear cell or endometrioid cancer.

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Abstract

OBJECTIVE: To investigate the clinical features of patients in Japan with malignant transformation of ovarian endometrioma. PATIENTS: Thirty-three patients diagnosed with ovarian cancer presumably arising from endometrioma were recruited retrospectively. These patients had been followed for at least 2 years after the ovarian endometrioma diagnosis, then continued to be followed after they had been found to have malignant transformation. RESULTS: The average age of the patients was 47.7 ± 9.3 years; 75.7% were premenopausal at the time of diagnosis of ovarian cancer. Among the 33 patients, ovarian cancer developed in the ipsilateral ovary of 6 patients with endometrioma after cystectomy. Twenty-eight patients were diagnosed with stage I ovarian cancer, and major histotypes were clear cell in 23 cases and endometrioid in 8. Before surgery for cancer, mural nodules within the endometriomas were detected in 32 patients, and 1 patient had a small 3-mm nodule. In 30 patients, the diameter of the tumor doubled in size 6 months prior to the diagnosis of malignant transformation. The diameter of the endometrioma and the preoperative CA125 value did not significantly correlate. CONCLUSIONS: To detect malignant transformation of ovarian endometrioma early and precisely, the clinician should determine the existence of a mural nodule and assess the rapid growth of the endometrioma.

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Condition tags

mesh:D004715endometrioma

MeSH descriptors

Adenocarcinoma, Clear Cell Carcinoma, Endometrioid Cell Transformation, Neoplastic Endometriosis Ovarian Cysts Ovarian Neoplasms Adenocarcinoma, Clear Cell Adult Aged CA-125 Antigen Carcinoma, Endometrioid Cell Transformation, Neoplastic Endometriosis Endometriosis Endometriosis Endometriosis Female Follow-Up Studies Humans Japan

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