Etiology and Pathogenesis of Epithelial Ovarian Cancer

Samuel C Mok, Joseph Kwong, William R Welch, Goli Samimi, Laurent Ozbun, Tomás Bonome, Tomas Bonome, Michael J Birrer, Ross S Berkowitz, Kwong‐Kwok Wong, Kwong-Kwok Wong
Disease markers · 2007 · vol. 23(5-6) , pp. 367–376 · doi:10.1155/2007/474320 · PMID:18057520 · PMC3851194 · W2135679869
review OA: gold CC0 ⤵ 6 in-corpus citations
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This review explores how the inflammatory tumor microenvironment, genetic variations, and epithelial cell interactions contribute to the diverse molecular mechanisms and phenotypes of epithelial ovarian cancer.

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Abstract

Ovarian cancer is complex disease composed of different histological grades and types. However, the underlying molecular mechanisms involved in the development of different phenotypes remain largely unknown. Epidemiological studies identified multiple exogenous and endogenous risk factors for ovarian cancer development. Among them, an inflammatory stromal microenvironment seems to play a critical role in the initiation of the disease. The interaction between such a microenvironment, genetic polymorphisms, and different epithelial components such as endosalpingiosis, endometriosis, and ovarian inclusion cyst in the ovarian cortex may induce different genetic changes identified in the epithelial component of different histological types of ovarian tumors. Genetic studies on different histological grades and types provide insight into the pathogenetic pathways for the development of different disease phenotypes. However, the link between all these genetic changes and the etiological factors remains to be established.

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Condition tags

endometriosis

MeSH descriptors

Carcinoma Carcinoma Ovarian Neoplasms Ovarian Neoplasms Carcinoma Carcinoma Female Humans Ovarian Neoplasms Ovarian Neoplasms Risk Factors

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