Endometriosis in monozygotic twins
Case report
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Six of eight monozygotic twin sisters with endometriosis also had the condition, suggesting a strong genetic component for endometriosis.
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Abstract
OBJECTIVE: To study the reproductive and medical history of monozygotic twin sisters and mothers of patients with endometriosis.
MATERIAL AND METHODS: Among 515 patients with endometriosis, eight had a monozygotic twin sister all of whom had had a gynecological laparoscopy or laparotomy. In addition, five of their mothers had had a laparotomy. Details about these 13 relatives were obtained either from medical records (ten cases) or by unmistakable reports from the proband (three cases).
RESULT: Six of the monozygotic twin sisters (75%) also had symptomatic endometriosis compared with 3.8% among other types of sisters (p < 0.0005). Three of the mothers (38%) had either endometriosis or adenomyosis.
CONCLUSION: This study gives support to the assumption that endometriosis has a genetic trait.
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- Monozygotic twins with endometriosis in matching locations at time of laparoscopy: A case report 2023
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- Endometriosis Research: From Bench to Bedside 2022
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- Placenta Previa Complicated with Endometriosis: Contemporary Clinical Management, Molecular Mechanisms, and Future Research Opportunities 2021
- Familial risk for endometriosis and its interaction with smoking, age at menarche and body mass index: a population-based cohort study among siblings 2021
- Endometriosis 2020
- Genetic, Epigenetic, and Steroidogenic Modulation Mechanisms in Endometriosis 2020
- The Role of the Molecular Genetic Approach in the Pathogenesis of Endometriosis 2019
- Infection as a potential cofactor in the genetic-epigenetic pathophysiology of endometriosis: a systematic review 2019
- Infection as a potential cofactor in the genetic-epigenetic pathophysiology of endometriosis: a systematic review. 2019
- The Pathogenesis of Endometriosis: Molecular and Cell Biology Insights 2019
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- Genetic Biomarkers for Endometriosis 2017
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- Endometriosis superficial y profunda: ¿ diferentes enfermedades? 2014
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- Endometriosis: Overview and Recommendations for Primary Care Nurse Practitioners 2010
- [Endometriosis and genetics: what responsibility for the genes?] 2010
- Meta-analysis of genome-wide association scans for genetic susceptibility to endometriosis in Japanese population 2010
- Bladder endometriosis, a remarkable resemblance in a monozygotic twin 2009
- ‘Nobody really knows what it is or how to treat it’: Why women with endometriosis do not comply with healthcare advice 2009
- Endometriosis genital y extragenital 2008
- Identical twins with ovarian endometriosis and mucinous borderline tumor: an unusual association 2008
- Dolor pélvico crónico e infertilidad como factores diagnósticos de endometriosis 2008
- Hibridação Genômica Comparativa em Endometriose 2008
- Chapter 10 Endometriosis and Autoimmunity 2008
- Familial aggregation of endometriosis in the Yale Series 2008
- Endometriosis 2008
- The search for genes contributing to endometriosis risk 2008
- [Management of endometriosis: clinical and biological assessment] 2007
- Endométriose génitale et extragénitale 2007
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