Analysis of the involvement of CCR5- 32 and CCR2-V64I variants in the development of endometriosis

Antiñolo G, G Antiñolo, Guillermo Antiñolo, R M Fernández, Fernández RM, J A Noval, Noval JA, Moliní JL, J L Moliní, S Borrego, Borrego S
Molecular human reproduction · 2004 · vol. 10(3) , pp. 155–157 · doi:10.1093/molehr/gah026 · PMID:14981141 · W2144948893
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This study investigated the CCR5-Delta32 and CCR2-V64I variants for association with endometriosis in Spanish women but found no significant differences between cases and controls.

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Abstract

Several arguments support the proposal that the cytokine network plays a critical role in the aetiology of endometriosis. Among various chemokines, regulated-on-activation, normal-T-cell-expressed and -secreted (RANTES) and monocyte chemotactic protein 1 (MCP-1) concentrations have been shown to be increased in the peritoneal fluid of women with endometriosis. Some studies have demonstrated that, in the context of endometriosis, these chemokines are involved in apoptosis, angiogenesis and/or chemotaxis. Since the chemokines exert their effects by binding to their receptors, it would be plausible that factors affecting such interactions might play a role in the pathogenesis of endometriosis. Thus we postulated that the genes encoding CCR5 and CCR2, which are the receptors for RANTES and MCP-1 respectively, could be good candidate genes for the disease. We have used real-time PCR and FRET technologies to genotype and evaluate the variants CCR5-Delta32 and CCR2-V64I, as susceptibility factors in a cohort of Spanish women with endometriosis. No differences have been found in the frequencies of the two polymorphisms nor in the haplotype/genotype distribution between cases and controls. These data would suggest the lack of association between these polymorphisms and endometriosis in our population, although they do not permit us to discard completely a possible role of other variants within CCR5 and CCR2 genes in this pathology.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Receptors, CCR5 Endometriosis Endometriosis Female Haplotypes Humans Mutation Receptors, CCR5 Receptors, CCR5

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (21)

Cited by (7)

Source provenance

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