Evaluation of germline sequence variants within the promoter region of RANTES gene in a cohort of women with endometriosis from Spain

Guillermo Antiñolo, G Antiñolo, Antiñolo G, R M Fernández, Fernández RM, J A Noval, Noval JA, García-Lozano JC, J C García-Lozano, Borrego S, S Borrego, I Marcos, Marcos I, Moliní JL, J L Moliní
Molecular human reproduction · 2003 · vol. 9(8) , pp. 491–495 · doi:10.1093/molehr/gag057 · PMID:12837926 · W2113130400
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This study genotyped promoter variants in the RANTES gene in Spanish women with endometriosis and found no association with the disease.

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Abstract

The RANTES (regulated upon activation normal T cells expressed and secreted) chemokine, is known to be expressed in endometriotic lesions in a concentration correlating with the severity of endometriosis. Since it has been widely demonstrated that endometriosis has a genetic basis, we postulated that the gene encoding RANTES could be a good candidate gene for the disease. We have used fluorescence resonance energy transfer (FRET) technology to genotype and evaluate the role of the variants -403G-->A and -28C-->G, located within the promoter region of the gene, as susceptibility factors in a cohort of Spanish women with endometriosis. No differences have been found in the allelic frequencies of both variants nor in the haplotype/ genotype distribution between patients and controls. These data are consistent with the lack of association between these polymorphisms and endometriosis in our population. They do not exclude completely a possible role of other variants within RANTES gene in this pathology.

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Condition tags

endometriosis

MeSH descriptors

Chemokine CCL5 Endometriosis Polymorphism, Genetic Polymorphism, Genetic Promoter Regions, Genetic Promoter Regions, Genetic Adult Adult Base Sequence Base Sequence Chemokine CCL5 Chemokine CCL5 Cohort Studies Cohort Studies Endometriosis Endometriosis Endometriosis Female Female Fluorescence Resonance Energy Transfer

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (51)

Cited by (6)

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