[Association of tumor necrosis factors-beta gene polymorphism with endometriosis in women in Guangdong Province].
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This study investigated TNF-beta gene +252 site polymorphism in Guangdong women, finding allele A and AA genotype significantly increased endometriosis risk.
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Abstract
OBJECTIVE: To study the polymorphism of +252 site in intron 1 of tumor necrosis factor (TNF)-beta gene in relation to genetic susceptibility of endometriosis. METHODS: Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) was employed to detect the polymorphism of +252 site in intron 1 of TNF-beta gene in 82 Chinese Han patients with endometriosis in Guangdong Province and 80 Han patients without endometriosis (control group), and the relation between TNF gene polymorphism and the risk of endometriosis was analyzed. RESULTS: The +252 site of TNF-beta allele and genotype distribution showed significant difference between endometriosis and control groups (Chi2=6.562, P<0.05; chi2=6.562, P<0.05), and relative risk of endometriosis in relation to allele A was increased by 1.793 fold. The risk of endometriosis was 3.33-fold higher in women of AA genotype than those of GG genotype (Chi2=6.562, P<0.05). CONCLUSIONS: Allele A in TNF-beta gene +252 site can significantly increase the relative risk of endometriosis in women in Guangdong, among which TNF-beta AA genotype might be one of the genetic susceptible factors for endometriosis.
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Cited by (6)
- Evaluation of Tumor Necrosis Factor Alpha Polymorphism Frequencies in Endometriosis. 2015
- Study of association between promoter tumor necrosing factor alpha gene polymorphisms in -850T/C, -863 A/C, and endometriosis 2014
- Tumor Necrosis Factor and Interleukin‐6 Gene Polymorphisms and Endometriosis Risk in Asians: A Systematic Review and Meta‐Analysis 2013
- Tumor necrosis factor alpha –C850T polymorphism is significantly associated with endometriosis in Asian Indian women 2009
- Functional genetic polymorphisms and female reproductive disorders: Part II--endometriosis 2008
- Endometriosis and Genetic Polymorphisms 2007
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