Advanced biomedical research

BackgroundDecreased Ovarian Reserve (DOR) is a significant challenge in infertility treatment. This study, which compared the effects of Novel Dual Trigger and Delayed Human Chorionic Gonadotropin (HCG), holds promise for improving IVF outc…

BackgroundEctopic pregnancy (EP) is one of the critical health conditions worldwide. Letrozole, an aromatase inhibitor that suppresses peripheral conversion of androgens to estrogens, has recently been introduced as a low-cost and minimal s…

BackgroundAngiomiRs, a group of microRNAs, target angiogenesis-related genes such as VEGF. Angiogenesis is crucial for endometrial receptivity and all stages of pregnancy. Research indicates that steroid concentrations can affect molecular …

BACKGROUND: Vulvovaginal Candidiasis (VVC) is a prevalent and complex health issue in women. With the rising resistance to synthetic antifungal medications, there is a growing emphasis on exploring natural remedies that minimize disruption …

BackgroundPolyps are a common diagnosis in women of different ages. They can cause a variety of symptoms from bleeding to infertility and can even be the progenitor for malignancies.Materials and methodsThis was a retrospective cohort study…

BACKGROUND: Endometriosis is defined as the existence of endometrial glands and stroma outside the uterine cavity. This disease is responsible for about 15% of the indications for assisted reproductive technologies (ART). MATERIALS AND MET…

BackgroundThe quality of the luteal phase is the most important issue affecting pregnancy outcomes in assisted reproductive technology (ART). Luteal-phase support with the administration of gonadotropin-releasing hormone (GnRH) agonist or p…

BackgroundCA125 levels show a variation in premenopausal women during the menstrual cycle. Moreover, various modifiable and non-modifiable factors affect its value which needs to be taken into account while interpreting the results. The stu…

BackgroundEvaluation of ovarian tumors based on tumor markers could have high clinical importance. In this study, we aimed to assess the predictive value of HE4 and Risk of Ovarian Malignancy Algorithm (ROMA) compared to CA-125 in the Malig…

BACKGROUND: Endometriosis is a female reproductive system disease in which the endometrial tissue is found in other women's organs. Various factors are effective in the development of endometriosis, and because of the interaction of genetic…

BackgroundAsherman syndrome is a controversial issue in obstetrics and gynecology without any consensus on its management and treatment. It is characterized by variable lesions inside the uterine cavity and also causes menstrual irregularit…

BackgroundAccording to the bioinformatics analyses and previous studies, bone morphogenetic protein receptor type 1B (BMPR1B) dysregulation could remarkably affect breast cancer (BC) status as a potential biomarker and tumor suppressor. The…

Lipoma is an uncommon mesenchymal tumor of the colon. They are typically symptom free, the large lipomas within the colon are rare, and can cause obstruction, bleeding, or intussusception. Intussusception is comparatively common in pediatri…

BackgroundCA125 is the most used tumor marker for ovarian cancer monitoring and diagnosis. This study aimed to evaluate the capacity to predict malignancy in women with adnexal tumors using CA125 measurement and ultrasound criteria before t…

BackgroundSacroiliac pain is one of the causes of low back pain, representing with discomfort and tenderness in the sacroiliac joint. Interventional procedures might be beneficial in cases unresponsive to medical treatments. Here, we aimed …

BackgroundHysterectomy is one of the most common gynecology surgeries. This study aimed to compare perioperative bleeding in transabdominal and transvaginal hysterectomy.Materials and methodsThis prospective, double-blind, randomized, contr…

BackgroundIntra-abdominal adhesions after surgery are usually in the form of bands and can annoy the patient throughout life causing repeated surgical procedures. Therefore, any action to prevent adhesions after surgery can increase longevi…

BackgroundInfertility, as one of the most common gynecological disorders, affects many people worldwide. To choose the clinical treatment, correct assessment of tubal patency can provide an important clue; therefore, it is considered as one…

BackgroundOne of the consequences of toxoplasmosis is the risk of passing it from mother to fetus and the onset of congenital toxoplasmosis during pregnancy. The purpose of this study was to evaluate the B1 gene of Toxoplasma gondii in the …

BACKGROUND: Acute pelvic inflammatory disease (PID) is a common reason for infertility. This study aimed to evaluate the frequency distribution of endometritis in women with unexplained infertility and comparison with frequency distribution…

BackgroundAngiogenesis plays a major role in endometrial receptivity and thickening of the endometrium immediately before implantation. The aim of the present work was to evaluate the antiangiogenic properties of epigallocatechin-3-gallate …

BackgroundOvarian angiogenesis (OA) remains in lifetime and normal ovarian function depends to this continual remodeling of a complex vascular system. Endometrial thickness (ET) is one of the strongest predictors of successful implantation …

BACKGROUND: Serum antimullerian hormone (AMH) proposed to be a reliable marker of ovarian reserve; the aim of this study was to evaluate the influence and value of laparoscopic management in endometriosis as measured by serum AMH levels. MA…

Despite high expectations of safer, effective, economical, longer acting contraceptives, to date, there are no licensed contraceptive vaccines available in the market. Nevertheless, a role for vaccines undoubtedly exists as an aid to birth …

The mucosal immune system in the female reproductive tract (FRT) is well equipped to meet the sexually transmitted pathogens, allogeneic sperm, and the immunologically distinct fetus. Analysis of the FRT indicates that epithelial cells prov…