КЛИНИКО-МОРФОЛОГИЧЕСКИЙ АНАЛИЗ ГЕНИТАЛЬНОГО ЭНДОМЕТРИОЗА

Clinical and morphological analysis of 125 cases of various forms of genital endometriosis (adenomyosis and ovarian endometriosis) was carried out. Main risk factors, clinical features and putative mechanisms of development of adenomyosis and ovarian endometriosis were analyzed. It was established, that adenomyosis develops predominantly in women during premenopausal, menopausal and postmenopausal periods (after 40 years) on the background of multiple pregnancy interruptions. Adenomyosis development in most cases is accompanied by development of multiple interstitial myomatous nodes, endometrium hyperplasia and fi brotic and cystic transformation of the ovaries. Ovarian endometriosis develops only in young women of reproductive age (up to 30 years) and in most cases is not associated with interruption of pregnancy. Pathomorphological peculiarities of ovarian endometriosis (pronounced hemosiderosis) and high level of oncogene CA-125 in serum allow to conclude, that ovarian alterations of unknown etiology and development of reparative processes on the background of retrograde infl ux of endometrial structures into circulation with their uterine outside ectopia play an important role in origin of ovarian endometriosis.