Association between interleukin-10 promoter polymorphisms and endometriosis: a meta-analysis

Fan W, Wei Fan, Shangwei Li, Li S, Chen Q, Qiong Chen, Huang Z, Zhongying Huang, Ma Q, Qianhong Ma, Zhun Xiao, Xiao Z
Gene · 2012 · vol. 515(1) , pp. 49–55 · doi:10.1016/j.gene.2012.11.037 · PMID:23237776 · W2013524048
Systematic review / meta-analysis OA: closed CC0 ⤵ 14 in-corpus citations
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This meta-analysis examined the association between interleukin-10 promoter polymorphisms and endometriosis, finding a potential link.

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Abstract

To investigate the influence of the interleukin-10 gene promoter polymorphisms on the susceptibility of endometriosis, we examined the association by performing a meta-analysis. The PubMed, Embase, HuGE Navigator and CNKI were searched to identify eligible studies. We then conducted a meta-analysis to examine the association between interleukin-10 gene promoter polymorphisms and endometriosis. Eight case-control studies which examined the association between the IL-10 gene promoter polymorphisms and the susceptibility to endometriosis were finally included in the meta-analysis. Meta-analysis of the IL-10 -592 A/C polymorphisms showed a significant increased risk of endometriosis in the overall and Asian population in all genetic models and allele contrast. However, meta-analysis of the IL-10 -1082 A/G and IL-10 -819 T/C polymorphisms showed no association with endometriosis in all genetic models and allele contrast in the overall and Asian population samples. In addition, there was not a significant association between the IL-10 -592 A/C gene promoter polymorphisms with the severity of endometriosis. In conclusion, this meta-analysis suggests that the IL-10 -592 A/C polymorphisms conferred susceptibility to endometriosis. However, no associations were found between the IL-10 -1082 A/G and -819 T/C polymorphisms and susceptibility to endometriosis. Further studies are required to elucidate these associations more clearly.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Genetic Predisposition to Disease Genetic Predisposition to Disease Interleukin-10 Polymorphism, Single Nucleotide Polymorphism, Single Nucleotide Promoter Regions, Genetic Promoter Regions, Genetic Alleles Alleles Endometriosis Endometriosis Endometriosis Female Female Genotype Genotype Humans Humans Interleukin-10

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (36)

Cited by (14)

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