Relationship between IL-10 promoter gene polymorphisms and the susceptibility to endometriosis

Pei He; Jun LIN; Xin-Mei Zhang; Lin Deng; Jun-Yan Ma; Junyan Ma

doi:10.3724/sp.j.1005.2009.00479

Relationship between IL-10 promoter gene polymorphisms and the susceptibility to endometriosis

Pei He, Jun LIN, Xin-Mei Zhang, Lin Deng, Jun-Yan Ma, Junyan Ma

Yi chuan = Hereditas · 2009 · vol. 31(5) , pp. 479–484 · doi:10.3724/sp.j.1005.2009.00479 · PMID:19586841 · W2462112547

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Abstract

The purpose of this study was to investigate the relationship between IL-10 promoter gene polymorphism and the susceptibility to endometriosis (EMs) in Chinese population. Amplification refractory mutation system polymerase chain reactions (ARMS-PCR) and DNA sequencing were performed to detect polymorphism of -1082G/A site and PCR-RFLP was used to determine the genotypes in -819T/C and -592A/C sites. One hundred and nineteen Chinese women with different stage EMs and 120 controls were employed in this study. Although there were no significant differences in the polymorphism of -1082 site between two groups (P>0.05), the frequencies of -819C, -592C alleles and -819 CC+TC, -592 CC+AC genotypes were significantly increased in EMs patients compared with the controls (P<0.05). The frequencies of -819C, -592C alleles and -819 CC+TC, -592 CC+AC genotypes were significantly increased in III-IV EMs patients compared with I-IIMs or controls (P<0.01). This suggests that polymorphisms of IL-10-819 (T/C) and -592 (A/C) may be associated with the susceptibility to EMs in Chinese population.

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Condition tags

endometriosis

MeSH descriptors

Disease Susceptibility Endometriosis Genetic Predisposition to Disease Interleukin-10 Promoter Regions, Genetic Adult Asian People Asian People Disease Susceptibility Endometriosis Female Humans Interleukin-10 Polymorphism, Genetic Polymorphism, Restriction Fragment Length Sequence Analysis, DNA Vascular Endothelial Growth Factor A Vascular Endothelial Growth Factor A Vascular Endothelial Growth Factor A

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References (11)

Different concentrations of interleukins in the peritoneal fluid of women with endometriosis: relationships with lymphocyte subsets via openalex
Endometriosis is associated with alterations in the relative abundance of proteins and IL-10 in the peritoneal fluid via openalex
W2005245112 via openalex
W2005845113 via openalex
W2016283253 via openalex
W2077040835 via openalex
W2088796135 via openalex
W2120083035 via openalex
W1985776841 via openalex
W2165530810 via openalex
W1993179974 via openalex

Cited by (4)

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[1] Different concentrations of interleukins in the peritoneal fluid of women with endometriosis: relationships with lymphocyte subsets 2004

[2] Endometriosis is associated with alterations in the relative abundance of proteins and IL-10 in the peritoneal fluid 2003