Maria Lúcia Carnevale Marin

article 2024

Soluble MICA in endometriosis pathophysiology: Impairs NK cell degranulation and effector functions

American journal of reproductive immunology (New York, N.Y. : 1989) ·doi:10.1111/aji.13830

PROBLEM: Endometriosis exhibits several immune dysfunctions, including deficient natural killer (NK) cell cytotoxicity. MICA (MHC class I chain-related molecule A) is induced by biological stress and soluble MICA (sMICA) negatively modulate…

article 2020

Inhibitory KIR2DL2 Gene: Risk for Deep Endometriosis in Euro-descendants

Reproductive sciences (Thousand Oaks, Calif.) ·doi:10.1007/s43032-020-00255-x

Endometriosis (EDT) is an inflammatory disease characterized by implantation/growth of endometrial tissue, glands, and/or stroma, outside the uterus. Reduced NK cell cytotoxic activity has been implicated in its pathogenesis, together with …

article 2019

HLA-G is upregulated in advanced endometriosis

European journal of obstetrics, gynecology, and reproductive biology ·doi:10.1016/j.ejogrb.2019.01.030

ObjectiveTo assess whether the HLA-G immunomodulatory protein is potentially involved in the pathophysiology of endometriosis or disease progression.Study designCross-sectional observational study of 227 women who underwent laparoscopy, bei…

article 2012

Patients With Endometriosis of the Rectosigmoid Have a Higher Percentage of Natural Killer Cells in Peripheral Blood

Journal of Minimally Invasive Gynecology ·doi:10.1016/j.jmig.2011.12.021

Study objectiveTo estimate the concentration of natural killer (NK) cells in the peripheral blood in patients with and without endometriosis.DesignCase-control study (Canadian Task Force classification II-2).SettingTertiary referral hospita…