Quality of life of endometriosis patients: focus on pain syndrome and neurological disorders

T.A. Lunko, H. V. Chaika, Sergii Konovalenko, A.S. Lunko
In: INTERNATIONAL NEUROLOGICAL JOURNAL · 2025 · vol. 21(2) , pp. 130–138 · doi:10.22141/2224-0713.21.2.2025.1162 · W4409762218
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⚙ AI-generated summary by claude@2026-06, 2026-06-28 ⓘ

This study evaluated quality of life in endometriosis patients receiving hormone therapy or peptide immunocorrection, finding both treatments improved pain, neurological symptoms, and overall quality of life.

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⚙ AI-generated deep summary by claude@2026-07, 2026-07-09 · read from full text ⓘ

The paper studied quality-of-life indicators in 120 patients aged 19–44 with genital endometriosis, using measures of quality of life, pain syndrome intensity, and neurological/psychiatric disorders tracked over time. Patients were randomized into two treatment groups after laparoscopic removal of endometrioma: one received hormone therapy and the other received peptide immunocorrection, with outcomes assessed longitudinally. Both groups started with similarly low quality-of-life index scores (~41 points), then showed increases at 6 months and by the end of follow-up (to 77.0 ± 5.5 and 84.0 ± 3.9 points, respectively) alongside decreased pain intensity and fewer patients reporting insomnia, depression, and anxiety. The study’s main limitation, as explicitly implied by its design, is that it compares two active interventions without detailing blinding or a non-treatment control arm. This paper is centrally about endometriosis — it evaluates how post-laparoscopic hormone therapy versus immune peptide correction affects pain-related quality of life and neurological comorbid symptoms in endometriosis patients.

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Abstract

Background. Endometriosis has a significant impact on the quality of life of patients, as it is a source of debilitating pain syndrome, leading to depression, anxiety and sleep disorders. Therefore, studying the possibilities of effective treatment of this disease and assessing the quality of life indicators of patients is a relevant clinical task. The purpose was to investigate the quality of life indicators in patients with endometriosis using the assessment of the quality of life index, the presence and intensity of pain syndrome, as well as neurological disorders in dynamics. Materials and methods. One hundred and twenty patients with genital endometriosis aged 19 to 44 years were divided into 2 study groups: in one group, hormone therapy was prescribed after laparoscopic removal of endometrioma, in another — peptide immunocorrection. During clinical monitoring, the quality of life index was assessed, and the effect of treatment on the dynamics of regression of clinical symptoms of the disease and its neurological consequences was analyzed. Results. Before the start of treatment, the quality of life index was at a relatively low level: 41.0 ± 4.8 points in group 1 and 41.0 ± 4.8 points in group 2. In group 1, it reached its maximum 6 months after surgery and was 77.0 ± 5.5 points, which is 75.0 % higher compared to baseline. In group 2, a similar dynamics of an increase in the quality of life index was observed, which at the end of the observation period was 84.0 ± 3.9 points exceeding the baseline by 104.9 %. In both study groups throughout the entire period of clinical monitoring, we observed a decrease in the intensity of the pain syndrome, as well as a gradual decrease in the number of patients complaining of insomnia, depressive disorders and anxiety. Conclusions. Surgical treatment of endometriosis, prescription of hormone therapy and the restoration of immune homeostasis of the involved organs are effective components of the comprehensive management of this category of patients. Reducing the intensity of chronic pain, and subsequently its elimination, inevitably improves the overall condition of patients and their quality of life.
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Quality of life of endometriosis patients: focus on pain syndrome and neurological disorders DOI: https://doi.org/10.22141/2224-0713.21.2.2025.1162Keywords: endometriosis, chronic pain, laparoscopy, hormone therapy, immunocorrection, immune peptides, insomnia, depression, quality of lifeAbstract Background. Endometriosis has a significant impact on the quality of life of patients, as it is a source of debilitating pain syndrome, leading to depression, anxiety and sleep disorders. Therefore, studying the possibilities of effective treatment of this disease and assessing the quality of life indicators of patients is a relevant clinical task. The purpose was to investigate the quality of life indicators in patients with endometriosis using the assessment of the quality of life index, the presence and intensity of pain syndrome, as well as neurological disorders in dynamics. Materials and methods. One hundred and twenty patients with genital endometriosis aged 19 to 44 years were divided into 2 study groups: in one group, hormone therapy was prescribed after laparoscopic removal of endometrioma, in another — peptide immunocorrection. During clinical monitoring, the quality of life index was assessed, and the effect of treatment on the dynamics of regression of clinical symptoms of the disease and its neurological consequences was analyzed. Results. Before the start of treatment, the quality of life index was at a relatively low level: 41.0 ± 4.8 points in group 1 and 41.0 ± 4.8 points in group 2. In group 1, it reached its maximum 6 months after surgery and was 77.0 ± 5.5 points, which is 75.0 % higher compared to baseline. In group 2, a similar dynamics of an increase in the quality of life index was observed, which at the end of the observation period was 84.0 ± 3.9 points exceeding the baseline by 104.9 %. In both study groups throughout the entire period of clinical monitoring, we observed a decrease in the intensity of the pain syndrome, as well as a gradual decrease in the number of patients complaining of insomnia, depressive disorders and anxiety. Conclusions. Surgical treatment of endometriosis, prescription of hormone therapy and the restoration of immune homeostasis of the involved organs are effective components of the comprehensive management of this category of patients. Reducing the intensity of chronic pain, and subsequently its elimination, inevitably improves the overall condition of patients and their quality of life. Downloads References

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