Prospects for the Treatment of Endometriosis: The Effect of Immune Peptides on the Reactivation of Immune Surveillance over Ectopic Endometrial Cells

Background. Genital endometriosis (GE) remains a significantly common disease, occurring in 0.5-5% of fertile women and in 25-40% of women with infertility. In patients with GE, there is a decrease in apoptosis in endometrial cells compared to healthy women, even more pronounced in ectopic foci, as a result of which their proliferative activity increases and the ability to abnormal implantation increases. Objective. Our task was to study the patterns of interaction of immune cells with ectopic endometrial cells, as well as to determine the molecular biological levers of influence on immune surveillance in endometriosis. Given the ability of ectopic cells to change the microenvironment in their favor, we aimed to find an effective tool to restore immune surveillance of endometrioma and thus offer a promising treatment for the disease. Method. For the purpose of writing this review article, we used the method of selection and analysis of scientific publications with open access. Results. The use of immune peptides in endometriosis, which are capable of activating regulatory macrophages and stimulating the recruitment of T-lymphocytes, opens up new possibilities for controlling the disease. Arecur, which contains immune peptides, including defensins and RJP-1, tunes immune cells to maximize their productivity against ectopic tissue, potentially creating conditions for the prevention of endometriosis-associated ovarian cancer. Conclusion. The use of immune peptides in endometriosis quite predictably contributes to more efficient work of local immunity. Immune cells potentiated with peptides not only independently attack and separate the intercellular connections in the endometrioma, but also provoke apoptosis of ectopic cells. The use of immune peptides in endometriosis opens up new prospects for increasing the effectiveness of treatment and prevention of this disease. | Published in | Journal of Gynecology and Obstetrics (Volume 8, Issue 5) | | DOI | 10.11648/j.jgo.20200805.14 | | Page(s) | 148-153 | | Creative Commons | This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. | | Copyright | Copyright © The Author(s), 2020. Published by Science Publishing Group |

Endometriosis, Ectopic Cells, Immune Surveillance, Immune Peptides, Arecur

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Prospects for the Treatment of Endometriosis: The Effect of Immune Peptides on the Reactivation of Immune Surveillance over Ectopic Endometrial Cells. J. Gynecol. Obstet. 2020, 8(5), 148-153. doi: 10.11648/j.jgo.20200805.14 AMA Style Natalia Zakharenko, Oleksii Tatskiy, Sergii Konovalenko. Prospects for the Treatment of Endometriosis: The Effect of Immune Peptides on the Reactivation of Immune Surveillance over Ectopic Endometrial Cells. J Gynecol Obstet. 2020;8(5):148-153. doi: 10.11648/j.jgo.20200805.14 - @article{10.11648/j.jgo.20200805.14, author = {Natalia Zakharenko and Oleksii Tatskiy and Sergii Konovalenko}, title = {Prospects for the Treatment of Endometriosis: The Effect of Immune Peptides on the Reactivation of Immune Surveillance over Ectopic Endometrial Cells}, journal = {Journal of Gynecology and Obstetrics}, volume = {8}, number = {5}, pages = {148-153}, doi = {10.11648/j.jgo.20200805.14}, url = {https://doi.org/10.11648/j.jgo.20200805.14}, eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.jgo.20200805.14}, abstract = {Background. Genital endometriosis (GE) remains a significantly common disease, occurring in 0.5-5% of fertile women and in 25-40% of women with infertility. In patients with GE, there is a decrease in apoptosis in endometrial cells compared to healthy women, even more pronounced in ectopic foci, as a result of which their proliferative activity increases and the ability to abnormal implantation increases. Objective. Our task was to study the patterns of interaction of immune cells with ectopic endometrial cells, as well as to determine the molecular biological levers of influence on immune surveillance in endometriosis. Given the ability of ectopic cells to change the microenvironment in their favor, we aimed to find an effective tool to restore immune surveillance of endometrioma and thus offer a promising treatment for the disease. Method. For the purpose of writing this review article, we used the method of selection and analysis of scientific publications with open access. Results. The use of immune peptides in endometriosis, which are capable of activating regulatory macrophages and stimulating the recruitment of T-lymphocytes, opens up new possibilities for controlling the disease. Arecur, which contains immune peptides, including defensins and RJP-1, tunes immune cells to maximize their productivity against ectopic tissue, potentially creating conditions for the prevention of endometriosis-associated ovarian cancer. Conclusion. The use of immune peptides in endometriosis quite predictably contributes to more efficient work of local immunity. Immune cells potentiated with peptides not only independently attack and separate the intercellular connections in the endometrioma, but also provoke apoptosis of ectopic cells. The use of immune peptides in endometriosis opens up new prospects for increasing the effectiveness of treatment and prevention of this disease.}, year = {2020} } - TY - JOUR T1 - Prospects for the Treatment of Endometriosis: The Effect of Immune Peptides on the Reactivation of Immune Surveillance over Ectopic Endometrial Cells AU - Natalia Zakharenko AU - Oleksii Tatskiy AU - Sergii Konovalenko Y1 - 2020/10/13 PY - 2020 N1 - https://doi.org/10.11648/j.jgo.20200805.14 DO - 10.11648/j.jgo.20200805.14 T2 - Journal of Gynecology and Obstetrics JF - Journal of Gynecology and Obstetrics JO - Journal of Gynecology and Obstetrics SP - 148 EP - 153 PB - Science Publishing Group SN - 2376-7820 UR - https://doi.org/10.11648/j.jgo.20200805.14 AB - Background. Genital endometriosis (GE) remains a significantly common disease, occurring in 0.5-5% of fertile women and in 25-40% of women with infertility. In patients with GE, there is a decrease in apoptosis in endometrial cells compared to healthy women, even more pronounced in ectopic foci, as a result of which their proliferative activity increases and the ability to abnormal implantation increases. Objective. Our task was to study the patterns of interaction of immune cells with ectopic endometrial cells, as well as to determine the molecular biological levers of influence on immune surveillance in endometriosis. Given the ability of ectopic cells to change the microenvironment in their favor, we aimed to find an effective tool to restore immune surveillance of endometrioma and thus offer a promising treatment for the disease. Method. For the purpose of writing this review article, we used the method of selection and analysis of scientific publications with open access. Results. The use of immune peptides in endometriosis, which are capable of activating regulatory macrophages and stimulating the recruitment of T-lymphocytes, opens up new possibilities for controlling the disease. Arecur, which contains immune peptides, including defensins and RJP-1, tunes immune cells to maximize their productivity against ectopic tissue, potentially creating conditions for the prevention of endometriosis-associated ovarian cancer. Conclusion. The use of immune peptides in endometriosis quite predictably contributes to more efficient work of local immunity. Immune cells potentiated with peptides not only independently attack and separate the intercellular connections in the endometrioma, but also provoke apoptosis of ectopic cells. The use of immune peptides in endometriosis opens up new prospects for increasing the effectiveness of treatment and prevention of this disease. VL - 8 IS - 5 ER - Author Information Copyright © 2012 -- 2026 Science Publishing Group – All rights reserved.