Anti-recurrent Immunocorrection in Gynecology Andrology and Proctology

In: International Journal of Immunology · 2020 · vol. 8(1) , pp. 1 · doi:10.11648/j.iji.20200801.11 · W3009534707
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Arecur®, containing exogenous peptides, demonstrated improved clinical efficacy for endocervicitis, dysplasia, endometrioma, prostatitis, and postoperative hemorrhoid care by mobilizing T-lymphocytes and exhibiting antibacterial, antiviral, and anti-inflammatory activities.

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The paper reports clinical experience using Arecur®, a preparation containing exogenous peptides (defensins and RJP-1), for multiple gynecologic/urogenital/proctologic indications, including endocervicitis and cervical dysplasia, endometrioma/endometriosis, chronic bacterial prostatitis, and postoperative rehabilitation after hemorrhoid removal. Across study groups described at a high level, Arecur® was associated with significantly better clinical efficacy, and the authors attribute effects to antibacterial/antiviral/anti-inflammatory/antitumor activity and mobilization of T-lymphocytes for immune recognition of infected and atypical cells. For endometriosis, they report regression of clinical symptoms and longer inter-relapsing intervals; for chronic bacterial prostatitis they report improved efficiency of etiotropic and symptomatic therapy, and for hemorrhoids they report improved rehabilitation dynamics and quality of life with fewer complications. This paper is centrally about endometriosis — it reports Arecur®’s proposed effect on regression of symptoms and prolongation of inter-relapsing intervals in patients with endometriosis/endometrioma.

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Abstract

The article provides evidence of clinical experience with the use of Arecur® for the treatment of endocervicitis and dysplasia of the cervix, endometrioma, chronic bacterial prostatitis, and for postoperative rehabilitation in patients after removal of hemorrhoids. Arecur® contains exogenous peptides of natural origin – anti-infective proteins of the group of defensins and RJP-1 and has antibacterial, antiviral, anti-inflammatory and antitumor activity. In the study groups, in which Arecur® was assigned to the patients, were reported significantly better clinical efficacy results. The ability of exogenous peptides to mobilize T-lymphocytes to identify and destroy infected and atypical cells determines the elimination of human papilloma virus and creates the conditions for reducing the risk of malignant cell transformation of cervical canal. Arecur®, by enhancing the immune supervision of ectopic endometrial cells, promotes regression of clinical symptoms and prolongation of inter-relapsing intervals in patients with endometriosis. In chronic bacterial prostatitis Arecur® increases the efficiency of etiotropic and symptomatic therapy. After surgical removal of hemorrhoid lesions, Arecur® provides more positive dynamics of rehabilitation, improves patients' quality of life and prevents complications. The obtained results allow us to reasonably recommend Arecur® as a medicine for anti-recurrent immunocorrection in gynecology, andrology and proctology.
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Abstract

The article provides evidence of clinical experience with the use of Arecur® for the treatment of endocervicitis and dysplasia of the cervix, endometrioma, chronic bacterial prostatitis, and for postoperative rehabilitation in patients after removal of hemorrhoids. Arecur® contains exogenous peptides of natural origin – anti-infective proteins of the group of defensins and RJP-1 and has antibacterial, antiviral, anti-inflammatory and antitumor activity. In the study groups, in which Arecur® was assigned to the patients, were reported significantly better clinical efficacy results. The ability of exogenous peptides to mobilize T-lymphocytes to identify and destroy infected and atypical cells determines the elimination of human papilloma virus and creates the conditions for reducing the risk of malignant cell transformation of cervical canal. Arecur®, by enhancing the immune supervision of ectopic endometrial cells, promotes regression of clinical symptoms and prolongation of inter-relapsing intervals in patients with endometriosis. In chronic bacterial prostatitis Arecur® increases the efficiency of etiotropic and symptomatic therapy. After surgical removal of hemorrhoid lesions, Arecur® provides more positive dynamics of rehabilitation, improves patients' quality of life and prevents complications. The obtained results allow us to reasonably recommend Arecur® as a medicine for anti-recurrent immunocorrection in gynecology, andrology and proctology. | Published in | International Journal of Immunology (Volume 8, Issue 1) | | DOI | 10.11648/j.iji.20200801.11 | | Page(s) | 1-8 | | Creative Commons | This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. | | Copyright | Copyright © The Author(s), 2020. Published by Science Publishing Group |

Keywords

Anti-Recurrent Immunocorrection, Exogenous Peptides, Arecur, Endocervicitis, Dysplasia, Human Papilloma Virus, Chlamydia, Endometrioma, Prostatitis, Hemorrhoids

References

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Chattopadhyay K., Hazra A., Dandara C. The combined risks ofreduced or increased function variants in cell death pathway genes differentially influence cervical cancer risk and herpes simplex virus type 2 infection among black Africans and the Mixed Ancestry population of South Africa. BMC Cancer. 2015; 15: 680. | | [10] | Wright TC, Stoler MH, Behrens CM, Sharma A, Zhang G, Wright TL. Primary cervical cancer screening with human papillomavirus: end of study results from the ATHENA study using HPV as the first-line screening test. Gynecol Oncol. 2015; 136: 189–197. | | [11] | D. Wohlmeister, D. Barreto Vianna, Vi. Etges Helfer, F. Gimenes, M. Lopes Consolaro, R. Bones Barcellos, M. L. Rossetti, L. Calil, A. Buffon, D. A. Pilger. Association of human papillomavirus and Chlamydia trachomatis with intraepithelial alterations in cervix samples. Mem Inst Oswaldo Cruz. 2016 Feb; 111 (2): 106–113. | | [12] | Melnikov SM, Tatskyi O. F. A new look at endometriosis: the role of restoring of full immune surveillance over ectopic cells of the endometrium. Women's health. 2017; № 7 (123). - P. 99-107. | | [13] | Hou XX, Wang XQ, Li DJ. Roles of regulatory T Cells in pathogenesis of endometriosis. Reprod Dev Med 2019; 3: 117-23. | | [14] | Yang S, Wang H, Li D, Li M. Role of Endometrial Autophagy in Physiological and Pathophysiological Processes. J Cancer. 2019 Jun 9; 10 (15): 3459-3471. | | [15] | Vallvé-Juanico J, Houshdaran S, Giudice LC. The endometrial immune environment of women with endometriosis. Hum Reprod Update. 2019 Sep 11; 25 (5): 564-591. | | [16] | Gorpinchenko I. I., Migov V. G. Treatment of patients with chronic calculous prostatitis using a peptide biostimulator Prostatilen: first results and prospects // Men's Health. - No 2 (45) 2013. - P. 37–40. | | [17] | Zaseda Y. I., Solomenny RI, Ganushchak A. V. The experience of radical conservative treatment of chronic calculous-fibrous and fibrous-calculous prostatitis // Ukrainian journal "Healthy, gender and psychosomatic medicine." - 2016.-- No. 1 (03). - P. 34–43. | | [18] | Zaseda Y. I., Tatskyi O. F. The effect of tissue accumulation of exogenous peptides is the key to understanding the mechanisms of harmonization of the immune homeostasis of patients with chronic bacterial prostatitis. Health of the man. 2017. № №1 (60). - P. 51 - 56. | | [19] | Podpriatov S, Apostolov V, Tatskyy O, Konovalenko S. Konovalenko V. Аngioprotective properties of exogenous peptides. Practitioner №1 (8)-2019; 20-24. | Cite This Article - APA Style Vasyl Beniuk, Vadym Goncharenko, Andrii Kurchenko, Oleksii Tatskyy, Sergii Konovalenko, et al. (2020). Anti-recurrent Immunocorrection in Gynecology Andrology and Proctology. International Journal of Immunology, 8(1), 1-8. https://doi.org/10.11648/j.iji.20200801.11 ACS Style Vasyl Beniuk; Vadym Goncharenko; Andrii Kurchenko; Oleksii Tatskyy; Sergii Konovalenko, et al. Anti-recurrent Immunocorrection in Gynecology Andrology and Proctology. Int. J. Immunol. 2020, 8(1), 1-8. doi: 10.11648/j.iji.20200801.11 AMA Style Vasyl Beniuk, Vadym Goncharenko, Andrii Kurchenko, Oleksii Tatskyy, Sergii Konovalenko, et al. Anti-recurrent Immunocorrection in Gynecology Andrology and Proctology. Int J Immunol. 2020;8(1):1-8. doi: 10.11648/j.iji.20200801.11 - @article{10.11648/j.iji.20200801.11, author = {Vasyl Beniuk and Vadym Goncharenko and Andrii Kurchenko and Oleksii Tatskyy and Sergii Konovalenko and Svitlana Vintoniuk and Sergii Melnikov and Kamil Nurimanov and Sergii Podpriatov}, title = {Anti-recurrent Immunocorrection in Gynecology Andrology and Proctology}, journal = {International Journal of Immunology}, volume = {8}, number = {1}, pages = {1-8}, doi = {10.11648/j.iji.20200801.11}, url = {https://doi.org/10.11648/j.iji.20200801.11}, eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.iji.20200801.11}, abstract = {The article provides evidence of clinical experience with the use of Arecur® for the treatment of endocervicitis and dysplasia of the cervix, endometrioma, chronic bacterial prostatitis, and for postoperative rehabilitation in patients after removal of hemorrhoids. Arecur® contains exogenous peptides of natural origin – anti-infective proteins of the group of defensins and RJP-1 and has antibacterial, antiviral, anti-inflammatory and antitumor activity. In the study groups, in which Arecur® was assigned to the patients, were reported significantly better clinical efficacy results. The ability of exogenous peptides to mobilize T-lymphocytes to identify and destroy infected and atypical cells determines the elimination of human papilloma virus and creates the conditions for reducing the risk of malignant cell transformation of cervical canal. Arecur®, by enhancing the immune supervision of ectopic endometrial cells, promotes regression of clinical symptoms and prolongation of inter-relapsing intervals in patients with endometriosis. In chronic bacterial prostatitis Arecur® increases the efficiency of etiotropic and symptomatic therapy. After surgical removal of hemorrhoid lesions, Arecur® provides more positive dynamics of rehabilitation, improves patients' quality of life and prevents complications. The obtained results allow us to reasonably recommend Arecur® as a medicine for anti-recurrent immunocorrection in gynecology, andrology and proctology.}, year = {2020} } - TY - JOUR T1 - Anti-recurrent Immunocorrection in Gynecology Andrology and Proctology AU - Vasyl Beniuk AU - Vadym Goncharenko AU - Andrii Kurchenko AU - Oleksii Tatskyy AU - Sergii Konovalenko AU - Svitlana Vintoniuk AU - Sergii Melnikov AU - Kamil Nurimanov AU - Sergii Podpriatov Y1 - 2020/03/02 PY - 2020 N1 - https://doi.org/10.11648/j.iji.20200801.11 DO - 10.11648/j.iji.20200801.11 T2 - International Journal of Immunology JF - International Journal of Immunology JO - International Journal of Immunology SP - 1 EP - 8 PB - Science Publishing Group SN - 2329-1753 UR - https://doi.org/10.11648/j.iji.20200801.11 AB - The article provides evidence of clinical experience with the use of Arecur® for the treatment of endocervicitis and dysplasia of the cervix, endometrioma, chronic bacterial prostatitis, and for postoperative rehabilitation in patients after removal of hemorrhoids. Arecur® contains exogenous peptides of natural origin – anti-infective proteins of the group of defensins and RJP-1 and has antibacterial, antiviral, anti-inflammatory and antitumor activity. In the study groups, in which Arecur® was assigned to the patients, were reported significantly better clinical efficacy results. The ability of exogenous peptides to mobilize T-lymphocytes to identify and destroy infected and atypical cells determines the elimination of human papilloma virus and creates the conditions for reducing the risk of malignant cell transformation of cervical canal. Arecur®, by enhancing the immune supervision of ectopic endometrial cells, promotes regression of clinical symptoms and prolongation of inter-relapsing intervals in patients with endometriosis. In chronic bacterial prostatitis Arecur® increases the efficiency of etiotropic and symptomatic therapy. After surgical removal of hemorrhoid lesions, Arecur® provides more positive dynamics of rehabilitation, improves patients' quality of life and prevents complications. The obtained results allow us to reasonably recommend Arecur® as a medicine for anti-recurrent immunocorrection in gynecology, andrology and proctology. VL - 8 IS - 1 ER - Author Information Copyright © 2012 -- 2026 Science Publishing Group – All rights reserved.

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