Additional file 3 of CCL20/CCR6 axis mediates macrophages to promote proliferation and migration of ESCs by blocking autophagic flux in endometriosis

Tan, Jiahuan, Xu, Tenghan, Gou, Yanling, Wang, Honglin, Liang, Zongwen, Cao, Yingying, Wang, Han, Yu, Yangyang, Jiao, Na, Zongfeng Zhang
2022 · doi:10.6084/m9.figshare.20329467.v1 · W6976600040
other OA: green CC0
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⚙ AI-generated summary by claude@2026-06, 2026-06-08 ⓘ

This study investigated the protein levels of autophagy, ERK1/2, NF-kB, and JAK/STAT pathway genes in ESCs activated by the CCL20/CCR6 axis, quantifying western blot bands and pathway ratios.

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Abstract

Additional file 3: Fig. 3. Expression of related signaling pathway genes in ESCs in response to activation of CCL20/CCR6 axis. (A) The protein level of different signaling genes in ESCs in response to activation of CCL20/CCR6 axis by western blot, including molecules of autophagy pathway (LC3, P62), ERK1/2 pathway (p-ERK1/2, ERK1/2), NF-kB pathway (NF-kB1, P65) and JAK/STAT pathway (p-JAK2, JAK2, p-STAT3, STAT3). (B) Quantification of the gray value of CCR6 western blot band. (C) Quantification of the gray value of LC3 and P62 western blot bands. (D) Statistical analysis of p-ERK1/2/ERK1/2 ratio. (E) Quantification of the gray value of P65 and NF-kB1 western blot band. (F) Statistical analysis of p-JAK2/JAK2 ratio and p-STAT3/STAT3 ratio. Data are presented as the mean ± SD of n=3 independent experiments. Statistical analysis was performed using Mann-Whitney test. **p<0.01,*p<0.05, ns, nonsignificant.

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endometriosis

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