CD26/DPPIV down-regulation in endometrial stromal cell migration in endometriosis

Tan CW, Chin Wen Tan, Yie Hou Lee, Lee YH, Tan HH, Heng Hao Tan, Lau MS, Matthew Sie Kuei Lau, Mahesh Choolani, Choolani M, Linda Griffith, Linda G. Griffith, Jerry Kok Yen Chan
Fertility and sterility · 2014 · vol. 102(1) , pp. 167–177.e9 · doi:10.1016/j.fertnstert.2014.04.001 · PMID:24825423 · W2074805304
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This study investigated the role of CD26/DPPIV down-regulation in endometrial stromal cell migration, a key process in endometriosis.

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Abstract

ObjectiveTo test the hypothesis that endometrial stromal cells (ESCs) in endometriosis exhibit increased cell motility under hypoxia.DesignProspective case-control study.SettingUniversity research laboratory.Patient(s)Women with endometriosis (n = 18) or benign gynecological disease (n=19).Intervention(s)Eutopic ESCs were cultured under normoxia (20% O2) or hypoxia (6.5% O2), and migration and invasion capacity assayed, with pathway-focused polymerase chain reaction (PCR) array and ELISAs performed. CD26/dipeptidyl peptidase IV (DPPIV) expression was determined by flow cytometric analysis and enzymatic activity assay. The ESCs supplemented with Diprotin A (CD26 inhibitor), stromal cell-derived factor-1α, or AMD3100 (C-X-C motif receptor 4; CXCR4 blocker) were assayed for their migratory potential.Main outcome measure(s)Endometrial stromal cell migration and invasion under hypoxia.Result(s)Endometriotic ESCs showed significantly higher migration and invasion through collagen gels under hypoxia compared with nonendometriotic ESCs. The PCR array revealed down-regulation of the migration inhibitor CD26/DPPIV and up-regulation of angiogenic factors (vascular endothelial growth factor A, C-X-C motif Ligand 6; CXCL6) in endometriotic ESCs under hypoxia. The CD26/DPPIV surface expression and activity as well as angiogenic protein secretions suggested that the molecular mechanisms underlying aberrant migratory and angiogenic behavior in endometriotic ESCs. A combinatorial treatment with diprotin A and stromal cell-derived factor-1α effectively enhanced migration and invasion preferentially in endometriotic ESCs cultured hypoxically.Conclusion(s)Loss of CD26/DPPIV under hypoxia and the subsequent increase in migratory and angiogenic factors may favor conditions for lesion development in endometriosis.

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Condition tags

endometriosis

MeSH descriptors

Cell Movement Cell Movement Dipeptidyl Peptidase 4 Endometriosis Endometrium Stromal Cells Adult Case-Control Studies Cell Hypoxia Cells, Cultured Chemokine CXCL6 Chemokine CXCL6 Chemokine CXCL6 Dipeptidyl Peptidase 4 Dipeptidyl Peptidase 4 Dipeptidyl-Peptidase IV Inhibitors Dipeptidyl-Peptidase IV Inhibitors Disease Progression Down-Regulation Endometriosis

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