Angiogenese und antiangiogene Therapien der Endometriose

Zusammenfassung Endometriose ist mit einer Prävalenzrate von 10–15% eine häufige gynäkologische Erkrankung von Frauen im reproduktionsfähigen Alter. Neben genetischen, immunologischen und Umweltfaktoren spielt auch eine gestörte Angiogenese eine entscheidende Rolle in der Ausbildung der Erkrankung. Da Endometrioseherde eine ausgeprägte Blutversorgung für ihr Überleben und ihre Entwicklung benötigen, sind sie—analog zu Tumormetastasen—von einer gesteigerten Neovaskularisation abhängig. Dieser Beitrag soll einen Einblick in die bei Endometriose gestörte Balance von angiostimulatorischen und angioinhibitorischen Faktoren sowie über potenzielle Therapien gegeben. Abstract Endometriosis is a common gynaecological disorder with a prevalence rate of 10–15% in women of reproductive age. Besides genetic, immunological and environmental factors, an impaired angiogenesis contributes to the development of the disease. 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Fertil Steril 79:770–778 Interessenkonflikt: Der korrespondierende Autor versichert, dass keine Verbindungen mit einer Firma, deren Produkt in dem Artikel genannt ist, oder einer Firma, die ein Konkurrenzprodukt vertreibt, bestehen. Author information Authors and Affiliations Corresponding author Rights and permissions About this article Cite this article Huber, A.W., Mueller, M.D. Angiogenese und antiangiogene Therapien der Endometriose. Gynäkologische Endokrinologie 2, 201–207 (2004). https://doi.org/10.1007/s10304-004-0084-3 Issue date: DOI: https://doi.org/10.1007/s10304-004-0084-3