{"paper_id":"e52621d0-3c80-4dca-82a2-8ca55067e45a","body_text":"Zusammenfassung\nEndometriose ist mit einer Prävalenzrate von 10–15% eine häufige gynäkologische Erkrankung von Frauen im reproduktionsfähigen Alter. Neben genetischen, immunologischen und Umweltfaktoren spielt auch eine gestörte Angiogenese eine entscheidende Rolle in der Ausbildung der Erkrankung. Da Endometrioseherde eine ausgeprägte Blutversorgung für ihr Überleben und ihre Entwicklung benötigen, sind sie—analog zu Tumormetastasen—von einer gesteigerten Neovaskularisation abhängig. Dieser Beitrag soll einen Einblick in die bei Endometriose gestörte Balance von angiostimulatorischen und angioinhibitorischen Faktoren sowie über potenzielle Therapien gegeben.\nAbstract\nEndometriosis is a common gynaecological disorder with a prevalence rate of 10–15% in women of reproductive age. Besides genetic, immunological and environmental factors, an impaired angiogenesis contributes to the development of the disease. As endometriotic implants need sufficient blood supply for their survival and development they are—in analogy to tumour metastases—dependent on increased neovascularisation. Based on the latest research, we elucidate in brief the disturbed balance of proangiogenic and angiogenesis-inhibiting molecules including potential therapies.\nSimilar content being viewed by others\nLiteratur\nBraun DP, Ding J, Dmowski WP (2002) Peritoneal fluid-mediated enhancement of eutopic and ectopic endometrial cell proliferation is dependent on tumor necrosis factor -α in women with endometriosis. Fertil Steril 78:727–732\nCohen T, Nahari D, Cerem LW et al. (1996) Interleukin 6 induces the expression of vascular endothelial growth factor. J Biol Chem 271:736–741\nDabrosin C, Gyorffy S, Margetts P et al. (2002) Therapeutic effect of angiostatin gene transfer in a murine model of endometriosis. Am J Pathol 161:909–918\nDaniel TO, Liu H, Morrow JD et al. 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Fertil Steril 79:770–778\nInteressenkonflikt:\nDer korrespondierende Autor versichert, dass keine Verbindungen mit einer Firma, deren Produkt in dem Artikel genannt ist, oder einer Firma, die ein Konkurrenzprodukt vertreibt, bestehen.\nAuthor information\nAuthors and Affiliations\nCorresponding author\nRights and permissions\nAbout this article\nCite this article\nHuber, A.W., Mueller, M.D. Angiogenese und antiangiogene Therapien der Endometriose. Gynäkologische Endokrinologie 2, 201–207 (2004). https://doi.org/10.1007/s10304-004-0084-3\nIssue date:\nDOI: https://doi.org/10.1007/s10304-004-0084-3","source_license":"CC0","license_restricted":false}