Establishment of an immortalized human endometrial stromal cell line with functional responses to ovarian stimuli

Munehiro Yuhki, Takashi Kajitani, Takakazu Mizuno, Yuko Aoki, Tetsuo Maruyama
Reproductive biology and endocrinology : RB&E · 2011 · vol. 9(1) , pp. 104 · doi:10.1186/1477-7827-9-104 · PMID:21801462 · PMC3160358 · W2166212359
article OA: gold CC0 ⤵ 5 in-corpus citations
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⚙ AI-generated summary by claude@2026-06, 2026-06-08 ⓘ

An immortalized human endometrial stromal cell line, KC02-44D, was developed and demonstrated similar functional responses to ovarian stimuli as primary endometrial stromal cells.

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Abstract

Studies on the mechanisms of decidualization and endometriosis are often hampered by lack of primary endometrial cells. To facilitate in vitro studies, we established a human endometrial stromal cell line, KC02-44D, immortalized with human telomerase reverse transcriptase. Upon exposure to ovarian stimuli, KC02-44D cells showed similar cytoskeletal marker or gene expression and biochemical phenotype to primary endometrial stromal cells. KC02-44D would be useful for studies of human endometrial function and its associated pathologies.

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Condition tags

endometriosis

MeSH descriptors

Cell Line Endometrium Stromal Cells Bucladesine Bucladesine CD13 Antigens CD13 Antigens Decidua Decidua Decidua Down-Regulation Endometrium Estradiol Estradiol Female Humans Interleukin-1beta Interleukin-1beta Medroxyprogesterone Acetate Medroxyprogesterone Acetate

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