Effect of human umbilical cord mesenchymal stem cells on endometriotic cell proliferation and apoptosis

Xu LN, Lei‐Bo Xu, L N Xu, N. Lin, Lin N, Ning Lin, B N Xu, Xu BN, Bing Xu, J B Li, Li JB, Jinbo Li, S Q Chen, Shaoqing Chen, Shuqin Chen
Genetics and molecular research : GMR · 2015 · vol. 14(4) , pp. 16553–16561 · doi:10.4238/2015.december.11.2 · PMID:26681001 · W2462403963
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Human umbilical cord mesenchymal stem cells inhibited endometriotic cell proliferation and increased apoptosis in vitro, potentially via PTEN upregulation.

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Abstract

The objective of this study was to observe the effects of human umbilical cord mesenchymal stem cells (UCMSCs) on the proliferation and apoptosis of endometriotic cells. Endometriotic cells and UCMSCs were primarily cultured in vitro. In the experimental group, a UCMSC and endometriotic cell non-contact co-culture system was established. The control group consisted of 1 x 10(5) endometriotic cells cultured alone. The proliferation and apoptosis of endometriotic cells were respectively detected using the MTT method and flow cytometry. The mRNA expression level of the tensin homologue gene (PTEN) in endometriotic cells was detected by reverse transcription-polymerase chain reaction amplification. Compared with the control group, the proliferation of endometriotic cells in the experimental group was clearly inhibited (P < 0.05) and time-dependent (P < 0.05). In addition, the number of apoptotic cells were significantly increased (P < 0.05), and the amount of cells, which entered S phase from G1 phase, decreased significantly. Furthermore, the mRNA expression level of the PTEN gene in the experimental group was significantly higher than in the control group (P < 0.05). These results suggest that UCMSCs might inhibit the proliferation of human endometriotic cells in vitro and promote their apoptosis by upregulating the expression of PTEN.

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Condition tags

endometriosis

MeSH descriptors

Apoptosis Cell Proliferation Endometriosis Endometrium Mesenchymal Stem Cells Adult Cells, Cultured Coculture Techniques Endometriosis Endometrium Endometrium Female Humans Mesenchymal Stem Cells Mesenchymal Stem Cells Middle Aged PTEN Phosphohydrolase PTEN Phosphohydrolase PTEN Phosphohydrolase Umbilical Cord

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