Mesenchymal stem cells to treat female infertility; future perspective and challenges: A review

Yasmeen Saeed, Liu X, Xiaocui Liu
International journal of reproductive biomedicine · 2022 · vol. 20(9) , pp. 709–722 · doi:10.18502/ijrm.v20i9.12061 · PMID:36340664 · PMC9619121 · W4306322085
review OA: gold CC0 ⤵ 4 in-corpus citations
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⚙ AI-generated summary by gemini-2.5-flash-lite, 2026-06-09 ⓘ

This review summarizes the therapeutic potential of mesenchymal stem cells for treating female infertility by examining their mechanisms in ovarian disorders and discussing preclinical/clinical applications, limitations, and future directions.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-09 · read from full text ⓘ

This paper is a narrative review discussing the use of mesenchymal stem cells as a potential therapy for female infertility, outlining future prospects and challenges. It focuses on the broader rationale and the current state of evidence rather than presenting new experimental data, synthesizing concerns such as feasibility and implementation barriers. The review’s main limitation is that it is not an original study and therefore does not provide definitive outcomes for efficacy or safety. This paper does not explicitly discuss endometriosis or adenomyosis; it was included in the corpus via a keyword match in the upstream search index.

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Abstract

Infertility negatively impacts the overall health and social life of affected individuals and couples. Female infertility is their inability to perceive pregnancy. To date, polycystic ovary syndrome, primary ovarian insufficiency, fallopian tube obstruction, endometriosis, and intrauterine synechiae have been identified as the primary causes of infertility in women. However, despite the mutual efforts of clinicians and research scientists, the development of an effective treatment modality has met little success in combating female infertility. Intriguingly, significant research has demonstrated mesenchymal stem cells as an optimal source for treating infertility disorders. Therefore, here we attempted to capsulize to date available studies to summarize the therapeutic potential of mesenchymal stem cells in combating infertility in women by focusing on the underlying mechanism through which stem cells can reduce the effects of ovarian disorders. Furthermore, we also discussed the preclinical and clinical application of stem cell therapy, their limitation, and the future perspective to minimize these limitations.
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Publication International Journal of Reproductive BioMedicine (IJRM) Record type Journal article Published 12 October 2022 Authors Yasmeen Saeed | Xiaocui Liu The publisher of this work supports multiple resolution. The work is available from the following locations: {'doi': '10.18502/ijrm.v20i9.12061', 'member_id': '7770', 'member': 'Knowledge E DMCC', 'container-title': 'International Journal of Reproductive BioMedicine (IJRM)', 'primary-resource': 'https://knepublishing.com/index.php/ijrm/article/view/12061', 'tld': 'knepublishing.com', 'clearbit-logo': '/static/no_logo.svg', 'coaccess': [], 'multiple-resolution': [{'url': 'https://ijrm.ssu.ac.ir/article-1-2283-en.html', 'tld': 'ssu.ac.ir', 'clearbit-logo': '/static/no_logo.svg'}, {'url': 'https://knepublishing.com/index.php/ijrm/article/view/12061', 'tld': 'knepublishing.com', 'clearbit-logo': '/static/no_logo.svg'}], 'type': 'JOURNAL ARTICLE', 'published_date': '12 October 2022', 'publication': 'International Journal of Reproductive BioMedicine (IJRM)', 'title': 'Mesenchymal stem cells to treat female infertility; future perspective and challenges: A review', 'name': None, 'id': None, 'location': None, 'display_doi': 'https://doi.org/10.18502/ijrm.v20i9.12061', 'grant_info': None, 'grant_info_funders': None, 'grant_info_funder_ids': '', 'grant_info_type': None, 'multiple_lead_investigators': [], 'multiple_co_lead_investigators': [], 'multiple_investigators': [], 'finances': [], 'project_description': None, 'award_amount': None, 'award_start': None, 'funding_scheme': None, 'internal_award_number': None, 'editors': None, 'authors': 'Yasmeen Saeed | Xiaocui Liu', 'chairs': None, 'supplementary_ids': None} https://doi.org/10.18502/ijrm.v20i9.12061 JSON XML

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Condition tags

endometriosisinfertility

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