Spatial and temporal characterization of endometrial mesenchymal stem-like cells activity during the menstrual cycle

Shan Xu, Rachel Chan, Ernest Hung Yu Ng, William S.B. Yeung
In: Experimental Cell Research · 2016 · vol. 350(1) , pp. 184–189 · doi:10.1016/j.yexcr.2016.11.020 · PMID:27890645 · W2552877395
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Researchers characterized endometrial mesenchymal stem-like cell activity spatially and temporally throughout the menstrual cycle.

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Abstract

The human endometrium is a highly dynamic tissue with the ability to cyclically regenerate during the reproductive life. Endometrial mesenchymal stem-like cells (eMSCs) located throughout the endometrium have shown to functionally contribute to endometrial regeneration. In this study we examine whether the menstrual cycle stage and the location in the endometrial bilayer (superficial and deep portions of the endometrium) has an effect on stem cell activities of eMSCs (CD140b+CD146+ cells). Here we show the percentage and clonogenic ability of eMSCs were constant in the various stages of the menstrual cycle (menstrual, proliferative and secretory). However, eMSCs from the menstrual endometrium underwent significantly more rounds of self-renewal and enabled a greater total cell output than those from the secretory phase. Significantly more eMSCs were detected in the deeper portion of the endometrium compared to the superficial layer but their clonogenic and self-renewal activities remained similar. Our findings suggest that eMSCs are activated in the menstrual phase for the cyclical regeneration of the endometrium.

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