The perivascular niche of endometrial mesenchymal stromal/stem-like cells

Rachel Chan, Tianqi Li, Si‐Si Zhang, Yuan Fang, Jingwen Xu
In: Reproductive and Developmental Medicine · 2022 · vol. 6(4) , pp. 208–214 · doi:10.1097/rd9.0000000000000038 · W4296622077
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This review examines the perivascular niche of endometrial mesenchymal stromal/stem-like cells, focusing on CD140b+CD146+ pericytes and SUSD2+ perivascular cells and their role in uterine regeneration.

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Abstract

Human endometrium is a unique adult tissue that undergoes cyclical shedding, repair, and regeneration during a woman’s reproductive life. Over the past 2 decades, tremendous progress has been made towards the identification and characterization of endometrial stromal stem/progenitor cells . The substantial regeneration of vascularized stroma in the endometrium during the proliferative stages of each menstrual cycle is likely to be mediated by endometrial mesenchymal stromal/stem cells. This review focuses on the perivascular niche for CD140b + CD146 + pericytes and SUSD2 + perivascular cells. The identity, characteristics, and underlying mechanisms of uterine regeneration are also discussed.

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