Characterization of endometrial mesenchymal stem-like cells obtained by endometrial biopsy during routine diagnostics

Andreas N. Schüring, Nicole Schulte, Reinhard Kelsch, Albrecht Röpke, Ludwig Kiesel, Martin Götte
In: Fertility and Sterility · 2010 · vol. 95(1) , pp. 423–426 · doi:10.1016/j.fertnstert.2010.08.035 · PMID:20864098 · W2010545057
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This paper characterizes endometrial mesenchymal stem-like cells isolated from endometrial biopsies taken during routine diagnostic procedures.

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Abstract

Endometrial cell clones derived from in vitro cultured purified stromal cells obtained by endometrial biopsy display characteristic stem cell features, including clonality; long-term culturing properties; multilineage differentiation potential; expression of CD146, CD105, CD90, CD73, MSI1, NOTCH1, and SOX2; and absence of CD34 and CD14 expression. We conclude that adult stem cells are present in endometrial biopsies performed in a routine clinical setting, offering new large-scale approaches for future research, diagnostics, and therapies involving adult stem cells.

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