The elusive role of endometrial progenitor cells in immunoregulation and regenerative medicine: A brief review of current knowledge
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This review outlines the characteristics of endometrial stem/progenitor cells, summarizing their roles in immunoregulation, regenerative medicine, and endometriosis, and proposing therapeutic strategies for reproductive and cancerous diseases.
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Abstract
The human endometrium is a highly regenerative organ undergoing over 400 cycles of shedding and regeneration over a woman’s lifetime. This massive regenerative capacity is thought to have a stem cell basis, with human endometrial stromal stem cells having already been extensively studied. Endometrial stem cells can be divided into three categories: endometrial epithelial stem/progenitor cells, CD140b+CD146+ or SUSD2+ endometrial mesenchymal stem cells (eMSCs), and side population cells (SPs). Endometrial stem/progenitor cells in the menstruation blood are defined as menstrual stem cells (MenSCs). Due to their abundant sources, excellent proliferation rate, and self-transplantation capabilities, MenSCs are ideal candidates for cell-based therapy in regenerative medicine, inflammation, and immune-related diseases. In this manuscript we review the available literature and outline the characteristics of endometrial stem/progenitor cells, summarizing their roles in immunoregulation, regenerative medicine and endometriosis, through which we provide some novel therapeutic strategies for reproductive and cancerous diseases.
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Too few in-corpus citations on either side for a chart; here are the lists.
Cites (3)
- Endometrial stem/progenitor cells and their roles in immunity, clinical application, and endometriosis 2021
- Spatial and temporal characterization of endometrial mesenchymal stem-like cells activity during the menstrual cycle 2016
- Understanding the regulatory mechanisms of endometrial cells on activities of endometrial mesenchymal stem-like cells during menstruation 2020
References (21)
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