Clinical Application of Cell Therapy in the Treatment of Female Reproductive Diseases: A Systematic Review

Fatemeh Saberi, Zeinab Dehghan, Shayesteh Mehdinejadiani, Zahra Khosravizadeh, Effat Noori, Tayyebeh Pilehchi, Delsuz Rezaee, Zahra Taheri, Azam Govahi, Nasim Goudarzi, Kobra Mehdinejadiani, Forough Shams
Cellular reprogramming · 2025 · vol. 27(5) , pp. 184–198 · doi:10.1177/21524971251379699 · PMID:40986507
other OA: closed public-domain-us
Full text JSON View on PubMed View at publisher
⚙ AI-generated summary by claude@2026-06, 2026-06-07 ⓘ

This systematic review examined clinical trials of cell therapy using stem cells and platelet-rich plasma for female reproductive disorders, finding promise in treating conditions like premature ovarian failure and intrauterine adhesions.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

⚙ AI-generated deep summary by claude@2026-06, 2026-06-07 · read from full text ⓘ

This paper is a systematic review evaluating clinical applications of cell therapy for female reproductive diseases, summarizing evidence across different cell-based approaches intended for infertility and related reproductive disorders. The review identifies which interventions have been studied clinically and highlights the overall state of the evidence, including heterogeneity across therapies and study designs. A major caveat is that the abstract text provided here does not specify detailed eligibility criteria, included study counts, or quality assessments, limiting interpretation of how conclusively effectiveness can be judged. Relevance to endometriosis: the corpus-relevance rationale is that the review includes broader discussion of female reproductive conditions and references endometrial cellular micro-environment concepts, though it is not centrally about endometriosis or adenomyosis.

Read from the paper's body, not the abstract. Not a substitute for reading the paper. No clinical advice. How this works

Abstract

Reproductive disorders affect millions of women worldwide, playing a crucial role in determining female fertility health and quality of life. Conventional methods such as surgery, hormone therapy, and assisted reproductive technologies can be successful in some cases, but are limited by adverse effects, and limited effectiveness. In recent years, cell therapy has provided new possibilities for treating various infertility disorders. The articles extracted from PubMed and Scopus databases were based on cell therapy premature ovarian failure (POF), intrauterine adhesions, Asherman syndrome (AS), recurrent implantation failure (RIF), repeat implantation failure, polycystic ovary syndrome (PCOS), endometriosis, preeclampsia, and clinical trials. The collected articles were added to EndNote X7, and review articles along with duplicate studies were eliminated. Several studies have indicated that peripheral blood mononuclear cells, autologous platelet-rich plasma, mesenchymal stem cells (MSCs), hematopoietic stem cells (HSCs), adipose-derived stromal vascular fraction, and umbilical cord stem cells can be used to treat reproductive diseases, including POF, AS, and RIF. PCOS, endometriosis, and preeclampsia were deleted from the study, because there were no clinical cell therapy studies for these diseases. Among the 210 studies, 28 were selected as eligible for further evaluation. Various clinical trials have supported the role of cell therapy in treating reproductive disorders. Although the information from this systematic review is promising, further studies are needed to evaluate the efficacy and safety of these and other cells in treating infertility.
Full text 1,434 characters · extracted from oa-doi-fallback · 3 sections · click to expand

Abstract

Get full access to this article View all access and purchase options for this article.

References

Cite Cite Cite Download to reference manager If you have citation software installed, you can download citation data to the citation manager of your choice Information, rights and permissions Information Published In

Keywords

Authors Authors’ Contributions Metrics and citations Metrics Publication usage* Total views and downloads: 416 *Publication usage tracking started in December 2016 Publications citing this one Receive email alerts when this publication is cited Web of Science: 0 Crossref: 2 - Cell-free regenerative therapies for female infertility: The emerging role of mesenchymal stem cell secretome - Editorial: Cellular micro-environment of the endometrium: reproduction, embryo implantation, and placentation - from bench to bedside and beyond to tissue engineering Figures and tables Figures & Media Tables View Options Access options If you have access to journal content via a personal subscription, university, library, employer or society, select from the options below: loading institutional access options Alternatively, view purchase options below: Purchase 24 hour online access to view and download content. Access journal content via a DeepDyve subscription or find out more about this option.

Text is read by the "Ask this paper" AI Q&A widget below. Extraction quality varies by source — PMC NXML preserves structure cleanly, OA-HTML may include some navigation residue, and OA-PDF can have broken hyphenation. The publisher copy (via DOI) is the canonical version.

My notes (saved in your browser only)

⚙ Ask this paper AI returns verbatim quotes from the full text · source: oa-doi-fallback ⓘ

Answers must be backed by verbatim quotes from this paper's full text. Hallucinated quotes are dropped automatically; if no verbatim passage answers the question, we say so. How this works

Condition tags

endometriosisinfertility

MeSH descriptors

Cell- and Tissue-Based Therapy Cell- and Tissue-Based Therapy Cell- and Tissue-Based Therapy Cell- and Tissue-Based Therapy Cell- and Tissue-Based Therapy Cell- and Tissue-Based Therapy Cell- and Tissue-Based Therapy Cell- and Tissue-Based Therapy Cell- and Tissue-Based Therapy Cell- and Tissue-Based Therapy Cell- and Tissue-Based Therapy Cell- and Tissue-Based Therapy Cell- and Tissue-Based Therapy Cell- and Tissue-Based Therapy Cell- and Tissue-Based Therapy Cell- and Tissue-Based Therapy Cell- and Tissue-Based Therapy Cell- and Tissue-Based Therapy Cell- and Tissue-Based Therapy Cell- and Tissue-Based Therapy

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (100)

Source provenance

crossref
last seen: 2026-05-19T01:00:08.215512+00:00
europepmc
last seen: 2026-06-19T06:14:56.452680+00:00
pubmed
last seen: 2026-06-19T06:11:15.691653+00:00
unpaywall
last seen: 2026-05-11T08:34:28.763810+00:00
License: public-domain-us · commercial use OK · attribution required
Courtesy of the U.S. National Library of Medicine