Premature Ovarian Failure

Ertuğ Kovanci, Amy K. Schutt
In: Obstetrics and Gynecology Clinics of North America · 2015 · vol. 42(1) , pp. 153–161 · doi:10.1016/j.ogc.2014.10.004 · PMID:25681846 · W62892850
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This paper discusses premature ovarian failure in reproductive-aged women, highlighting its serious health consequences and emphasizing immediate estrogen therapy to prevent long-term risks while cautioning against applying postmenopausal treatment data.

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Abstract

Premature ovarian failure is a devastating diagnosis for reproductive-aged women. The diagnosis is relatively easy. However, it has serious health consequences, including psychological distress, infertility, osteoporosis, autoimmune disorders, ischemic heart disease, and increased risk for mortality. Management should be initiated immediately to prevent long-term consequences. Estrogen therapy is the mainstay of management. Postmenopausal estrogen therapy studies should not be used to determine the risks of treatment in these young women.

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