Cellular therapies for the endometrium: An update

Suzanna Queckbörner, Lindsay C. Davies, Carolina von Grothusen, Xavier Santamaría, Carlos Simón, Kristina Gemzell‐Danielsson
In: Acta Obstetricia et Gynecologica Scandinavica · 2019 · vol. 98(5) , pp. 672–677 · doi:10.1111/aogs.13598 · PMID:30815850 · W2919215660
review OA: bronze CC0 ⤵ 2 in-corpus citations
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⚙ AI-generated summary by claude@2026-06, 2026-06-11 ⓘ

This review updates the state of endometrial cell therapies, reporting promising preliminary results from recent trials for Asherman's syndrome and infertility, with further characterization and larger trials needed for clinical viability.

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Abstract

An update on the current state of endometrial cell therapies in terms of cell types, mechanisms of action, delivery, safety, regulatory frameworks and future perspectives. This review focuses on clinical trials using angiogenesis-promoting therapies and stromal therapies piloted in the last 10 years for alleviating Asherman's syndrome and long-term infertility. All studies present promising preliminary results, indicating increased endometrial thickness and resumed menstruation. Further characterization of individual cell products, their mode of action and larger clinical trials will be essential to establishing cell therapy as a viable option for the treatment of infertility and fertility preservation.

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infertility

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last seen: 2026-06-04T00:00:01.174412+00:00
License: CC0 · commercial use OK