Dysmenorrhea and Prostaglandins

M. Yusoff Dawood
In: Gynecologic Endocrinology · 1987 · pp. 405–421 · doi:10.1007/978-1-4613-2157-6_19 · W2596922
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⚙ AI-generated summary by claude@2026-06+body, 2026-06-08 ⓘ

Extracts from menstrual fluid were shown to stimulate smooth muscle contractions, later identified as prostaglandins, which are elevated in women with dysmenorrhea and reduced by NSAIDs.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-09 ⓘ

This chapter reviews historical and experimental research on dysmenorrhea and the role of prostaglandins, focusing on measurements of prostaglandins in menstrual fluid and endometrium from women with primary dysmenorrhea and in vitro smooth-muscle bioassays. It reports that women with primary dysmenorrhea have higher menstrual fluid prostaglandins than normal women, and that endometrial/menstrual fluid prostaglandins are increased in dysmenorrhea and can be reduced below normal with nonsteroidal anti-inflammatory drugs, with concomitant pain relief. The discussion is largely based on prior studies and pharmacologic observations rather than a single new, clearly defined study, and it does not uniformly address how consistent or causally specific prostaglandin elevations are across conditions and populations. Relevance to endometriosis: it discusses prostaglandins in menstrual blood/endometrium for dysmenorrhea and also cites and summarizes evidence on prostanoids in peritoneal fluid and endometriotic tissue, though its main focus is dysmenorrhea and prostaglandins.

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dysmenorrhea

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