REDUCTION OF MENSTRUAL BLOOD-LOSS BY PROSTAGLANDIN-SYNTHETASE INHIBITORS

AnneB.M. Anderson, John Guillebaud, P. J. Haynes, A. C. Turnbull
In: The Lancet · 1976 · vol. 307(7963) , pp. 774–776 · doi:10.1016/s0140-6736(76)91612-3 · W2156964116
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⚙ AI-generated summary by claude@2026-06, 2026-06-07 ⓘ

Prostaglandin-synthetase inhibitors were evaluated for their ability to reduce menstrual blood loss.

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Abstract

Six patients with menorrhagia due to dysfunctional uterine bleeding and one patient with an intrauterine contraceptive device were treated with prostaglandin-synthetase inhibitors in an attempt to reduce their excessive menstrual blood-loss. Mefenamic acid (six patients) or flufenamic acid (one patient) taken during menstruation for 2-3 cycles reduced menstrual loss in each patient. These preliminary observations suggest a new treatment for a common gynaecological problem and could imply that prostaglandins are involved in the aetiology of excessive menstrual blood-loss in such patients.

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