Control of menorrhagia by the cyclo‐oxygenase inhibitors naproxen sodium and mefenamic acid

P. HALL, Pauline de la Μ. Hall, N. MACLACHLAN, Niels A. Thorn, N. THORN, M. W. E. NUDD, C. G. TAYLOR, Cassidy Taylor, D. B. Garrioch
BJOG: An International Journal of Obstetrics & Gynaecology · 1987 · vol. 94(6) , pp. 554–558 · doi:10.1111/j.1471-0528.1987.tb03150.x · PMID:3304401 · W2101962667
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⚙ AI-generated summary by claude@2026-06, 2026-06-08 ⓘ

Naproxen sodium and mefenamic acid reduced excessive menstrual bleeding by approximately 46-47% in a double-blind crossover study of 35 patients with menorrhagia.

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Abstract

Thirty-five patients with menorrhagia were treated in a double-blind crossover study with naproxen sodium and mefenamic acid after measurement of their blood loss during control menstrual cycles. Treatment with these compounds reduced the excessive bleeding by an average of 46 and 47% respectively. Drugs in the prostaglandin synthetase inhibitor group are considered to have an important place in the treatment of menorrhagia.

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