Endometriosis: The elusive epiphenomenon
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Abstract
The denervation-reinnervation view proposes that retrograde menstruation results from loss of normal, fundocervical polarity caused by injuries to uterine nerves. Injuries may be sporadic (following vaginal delivery) or recurrent (after persistent straining during defaecation) creating very different appearances at laparoscopy. Clinical symptoms of pelvic pain, menstrual problems, dyspareunia, and dysmenorrhoea result from aberrant reinnervation that may occur with, or without deposits of pelvic endometriosis. Endometrium, delivered by retrograde menstruation, adheres to any injured tissues in the lower pelvis. Classical 'endometriosis' is largely an epiphenomenon to underlying processes of denervation and reinnervation.
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Cited by (8)
- “Endometriosis”: A neuro-etiologic framework for its causes and consequences 2019
- Endometriosis-associated changes in serum levels of interferons and chemokines 2017
- “Endometriosis”—The Role of Radical Surgery in a Regional Pain Syndrome 2013
- Endometriosis: the consequence of uterine denervation–reinnervation 2011
- Letters and emails 2011
- The role of nuclear factor-kappa-B p50 subunit in the development of endometriosis 2010
- An unusual case of post-traumatic endometriosis involving the sciatic nerve in the right greater sciatic notch 2010
- Apoptosis and endometriosis 2010
Source provenance
- europepmc
- last seen: 2026-06-11T06:19:48.454388+00:00
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- pubmed
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- last seen: 2026-06-02T02:00:03.124865+00:00
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