{"paper_id":"98189ea8-b1cb-4eed-a694-d9435a560cea","body_text":"Abstract\nPurpose: The impact of endometriosis and unexplained infertility on follicular function and fertilization of oocytes in cycles totally unperturbed by exogenous gonadotrophins, when compared with controls with tubal damage, were examined.\nMethods: In natural cycles, without any exogenous gonadotropins, endocrine and ultrasonographic studies of follicular maturation in 18 women with minor endometriosis (41 cycles), 15 women with unexplained infertility (31 cycles), and 34 women with tubal damage (88 cycles) were performed.\nResults: The endometriosis group had a significantly longer follicular phase (median: 15,13, and 13 days). Both endometriosis and unexplained infertility had significantly reduced LH concentrations in follicular fluid compared with tubal damage (median: 12.1, 11.5, and 15.9 IU/L, respectively). Endometriosis was associated with a significantly reduced fertilization rate compared with unexplained infertility or tubal damage (46, 65, and 69%, respectively).\nConclusions: These data show continuing evidence of ovulatory dysfunction leading to reduced fertilization rates in women with minor endometriosis.\nSimilar content being viewed by others\nREFERENCES\nCahill DJ, Wardle PG, Maile LA, Harlow CR, Hull MGR: Pituitary-ovarian dysfunction as a cause for endometriosis-associated and unexplained infertility. Hum Reprod 1995;10:3142–3146\nWardle PG, Mitchell JD, McLaughlin EA, Ray BD, McDermott A, Hull MGR: Endometriosis and ovulatory disorder: Reduced fertilisation in vitro compared with tubal and unexplained infertility. 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In Current Status of Endometriosis—Research and Management (Proceedings, 3rd World Congress on Endometriosis), I Brosens, J Donnez (eds). Camforth, UK, Parthenon, 1993, pp 419–424\nCahill DJ, Wardle PG, Harlow CR, Hull MGR: Effect of progestogen therapy on follicular development related hormone concentrations and fertilization in vitro in unstimulated cycles and unexplained and endometriosis-associated infertility. Hum Reprod 1996;11:647–650\nAuthor information\nAuthors and Affiliations\nRights and permissions\nAbout this article\nCite this article\nCahill, D.J., Wardle, P.G., Maile, L.A. et al. Ovarian Dysfunction in Endometriosis-Associated and Unexplained Infertility. J Assist Reprod Genet 14, 554–557 (1997). https://doi.org/10.1023/A:1022568331845\nIssue date:\nDOI: https://doi.org/10.1023/A:1022568331845","source_license":"CC0","license_restricted":false}