Endometriosis-associated infertility treated by long-term gonadotropin-releasing hormone agonist administration and assisted fertilization

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Long-term GnRH-agonist suppression followed by assisted fertilization successfully treated infertility and relieved pain in two patients with endometriosis.

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The paper reports on two patients with long-lasting infertility associated with moderate and severe symptomatic endometriosis, treated with long-term gonadotropin-releasing hormone agonist suppression of ovarian function. Both patients experienced relief of endometriosis-related abdominal pain within the first month, and after an additional 3 to 5 months of treatment, assisted fertilization was performed, leading to ongoing pregnancies in both cases. The main limitation is that this is a very small case series with only two patients, providing no comparative control group. This paper is centrally about endometriosis — it describes endometriosis-associated infertility managed with long-term GnRH-agonist suppression followed by assisted fertilization.

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Abstract

Two patients with long-lasting infertility associated with moderate and severe symptomatic endometriosis were treated with long-term GnRH-agonist suppression of ovarian function. Both patients were relieved of their endometriosis-related abdominal pains during the first treatment month. After an additional treatment period of 3 to 5 months, assisted fertilization was performed, resulting in an ongoing pregnancy for both patients.
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Summary Two patients with long-lasting infertility associated with moderate and severe symptomatic endometriosis were treated with long-term GnRH-agonist suppression of ovarian function. Both patents were relieved of their endometriosis-related abdominal pains during the first treatment month. After an additional treatment period of 3 to 5 months, assisted fertilization was performed, resulting in an ongoing pregnancy for both patients. Access this article We’re sorry, something doesn't seem to be working properly. Please try refreshing the page. If that doesn't work, please contact support so we can address the problem. References Chillik CF, Acosta AA, Garcia JE, Perera S, Van Uem JFHM, Jones HW: The role of in vitro fertilization in infertile patients with endometriosis. Fertil Steril 1985;44:56–61 Åbyholm T, Tanbo T, Henriksen T, Magnus Ø: Preliminary experience with embryo intrafallopian transfer (EIFT). Int J Fertil (in press) Henriksen T, Åbyholm T, Tanbo T, Magnus Ø: Gamete intrafallopian transfer (GIFT). The results of 93 consecutive treatments. Acta Obstet Gynecol Scand 1989;68:197–200 Tanbo T, Åbyholm, T, Magnus Ø, Henriksen, T: Gonadotropin and ovarian steroid production in polycystic ovarian syndrome during suppression with a gonadotropin releasing hormone agonist. Gynecol Obstet Invest 1989;28:147–151 Lemay A, Maheux R, Hout C, Blanchet J, Faure N: Efficacy of intranasal of subcutaneous luteinizing hormone-releasing hormone agonist inhibition of ovarian function in the treatment of endometriosis. Am J Obstet Gynecol 1988;158:233–236 Schriock E, Monroe SE, Henzl M, Jaffe RB: Treatment of endometriosis with a potent agonist of gonadotropin-releasing hormone (nafarelin). Fertil Steril 1985;44:583–588 Steingold KA, Cedars M, Lu JK, Randle D, Judd HL, Meldrum DRO: Treatment of endometriosis with a long-acting gonadotropin-releasing hormone agonist. Obstet Gynecol 1987;69:403–411 Yovich JL, Matson PL, Richardson PA, Hilliard C: Hormonal profiles and embryo quality in women with severe endometriosis treated by in vitro fertilization and embryo transfer. Fertil Steril 1988;50:308–313 Serafini P, Stone B, Kerin J, Batzofin, J, Quinn P, Marrs R: An alternate approach to controlled ovarian hyperstimulation in “poor responders”: Pretreatment with a gonadotropin-releasing hormone analog. Fertil Steril 1988;49:90–95 Author information Authors and Affiliations Rights and permissions About this article Cite this article Dale, P.O., Tanbo, T. & Åbyholm, T. Endometriosis-associated infertility treated by long-term gonadotropin-releasing hormone agonist administration and assisted fertilization. J Assist Reprod Genet 7, 180–181 (1990). https://doi.org/10.1007/BF01135686 Received: Accepted: Issue date: DOI: https://doi.org/10.1007/BF01135686

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Condition tags

endometriosisinfertility

MeSH descriptors

Buserelin Endometriosis Fertilization in Vitro Infertility, Female Adult Buserelin Endometriosis Endometriosis Female Humans Infertility, Female Infertility, Female

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