Endometriosis-associated infertility treated by long-term gonadotropin-releasing hormone agonist administration and assisted fertilization
Long-term GnRH-agonist suppression followed by assisted fertilization successfully treated infertility and relieved pain in two patients with endometriosis.
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The paper reports on two patients with long-lasting infertility associated with moderate and severe symptomatic endometriosis, treated with long-term gonadotropin-releasing hormone agonist suppression of ovarian function. Both patients experienced relief of endometriosis-related abdominal pain within the first month, and after an additional 3 to 5 months of treatment, assisted fertilization was performed, leading to ongoing pregnancies in both cases. The main limitation is that this is a very small case series with only two patients, providing no comparative control group. This paper is centrally about endometriosis — it describes endometriosis-associated infertility managed with long-term GnRH-agonist suppression followed by assisted fertilization.
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References (9)
- Efficacy of intranasal or subcutaneous luteinizing hormone-releasing hormone agonist inhibition of ovarian function in the treatment of endometriosis via openalex
- Treatment of endometriosis with a long-acting gonadotropin-releasing hormone agonist. via openalex
- Treatment of endometriosis with a potent agonist of gonadotropin-releasing hormone (nafarelin) via openalex
- W2050791151 via openalex
- W1989017718 via openalex
- W2410273940 via openalex
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Cited by (9)
- Hormonal Therapies before In-Vitro Fertilization in Women with Endometriosis 2024
- Hormonal Therapies before in vitro fertilization in women with endometriosis: The Minotaur's Labyrinth and the Ariadne's Thread 2024
- Continuous oral contraceptives versus long-term pituitary desensitization prior to IVF/ICSI in moderate to severe endometriosis: study protocol of a non-inferiority randomized controlled trial 2019
- Continuous oral contraceptives versus long-term pituitary desensitization prior to IVF/ICSI in moderate to severe endometriosis: study protocol of a non-inferiority randomized controlled trial 2019
- Efficacy and safety of IVF/ICSI in patients with severe endometriosis after long-term pituitary down-regulation 2013
- Long-term use of gonadotropin-releasing hormone analogues before IVF in women with endometriosis 2007
- Long-term pituitary down-regulation before in vitro fertilization (IVF) for women with endometriosis 2006
- Long-term pituitary down-regulation before in vitro fertilization (IVF) for women with endometriosis 2004
- Menotropin stimulation after prolonged gonadotropin releasing hormone agonist pretreatment for in vitro fertilization in patients with endometriosis 1992
Source provenance
- europepmc
- last seen: 2026-08-22T06:09:51.966504+00:00
- openalex
- last seen: 2026-06-10T17:14:06.276822+00:00
- pubmed
- last seen: 2026-05-13T22:12:10.587122+00:00
- unpaywall
- last seen: 2026-08-22T06:23:50.750314+00:00