Hydrosalpinx treated with extended doxycycline does not compromise the success of in vitro fertilization

Bradley S. Hurst, B S Hurst, Hurst BS, Kathleen Tucker, K E Tucker, Tucker KE, Awoniyi CA, C A Awoniyi, Caleb A. Awoniyi, Schlaff WD, W D Schlaff, William D. Schlaff
Fertility and Sterility · 2001 · vol. 75(5) , pp. 1017–1019 · doi:10.1016/s0015-0282(01)01753-8 · PMID:11334919 · W2039585460
article OA: closed CC0 ⤵ 8 in-corpus citations
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This study investigated whether extended doxycycline treatment for hydrosalpinx negatively impacts in vitro fertilization success rates.

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Abstract

ObjectiveTo determine if extended treatment with doxycycline before and after an in vitro fertilization (IVF) procedure can minimize the detrimental effect of a hydrosalpinx.DesignRetrospective analysis.SettingUniversity IVF program.Patient(s)Patients undergoing IVF, including 17 with a hydrosalpinx, 25 with adhesions or proximal tubal occlusion, and 22 with endometriosis or unexplained infertility.Intervention(s)Women with a documented hydrosalpinx were prescribed doxycycline 100 mg twice daily starting 1 week before expected retrieval and continued until 6 days after retrieval. No antibiotics were prescribed in the other groups.Main outcome measure(s)Implantation rates and IVF outcomes.Result(s)Implantation rates were 30% for the doxycycline-treated group of patients with a hydrosalpinx, 27% for the group with tubal occlusion/adhesion, and 24% for the group with endometriosis or unexplained infertility. Eight (47%) of 17 patients with a hydrosalpinx had a live birth, compared with 11 (44%) of 25 for the group with tubal occlusion/adhesion and 12 (55%) of 22 for the group with endometriosis/unexplained infertility. There were no differences between the groups in patient age, number of oocytes retrieved, fertilization rate, or number of blastomeres of the transferred embryos.Conclusion(s)No detrimental effect of a hydrosalpinx was evident for patients treated with extended doxycycline. Tremendous cost savings can be realized if treatment with 2 weeks of an inexpensive antibiotic provides outcomes comparable to surgical correction of a hydrosalpinx before IVF.

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Condition tags

endometriosis

MeSH descriptors

Anti-Bacterial Agents Doxycycline Fallopian Tube Diseases Fertilization in Vitro Adult Anti-Bacterial Agents Anti-Bacterial Agents Birth Rate Doxycycline Doxycycline Embryo Transfer Endometriosis Endometriosis Fallopian Tube Diseases Fallopian Tube Diseases Female Fertilization in Vitro Humans Infant, Newborn Infertility, Female

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